基本信息
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Bio
Current research in my group focuses on further understanding the biology of lung, especially non-small cell lung cancer (NSCLC), through the establishment and molecular dissection of tumour models grown directly from patient tumours. These tumour models are established as patient-derived xenograft (PDX) in immune-deficient mice or as patient-derived organoid (PDO) in tissue culture dishes. We have demonstrated that the ability of a patient tumour to grow as PDX is associated with poorer prognosis for the patient and thus reflects aggressive cancer biology. In fact, this is consistent with higher success rates to establish PDX from tumours obtained (biopsied) from advanced-stage or metastatic patients. We have also reported that both PDX and PDO models mimic the pathological and molecular features of patient tumours used to establish them. We are presently using these models and the technologies to study genes, protein and cellular processes that determine or influence: (1) the metastatic behaviour of NSCLC, (2) resistance to specific therapy, and (3) small subpopulation of tumour cells that evade killing during treatment with highly effective therapies.
Research Interests
Papers共 1167 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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合作机构
Lung Cancer (2024): 107863-107863
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024)
Mohamed Bourmoum,Nikolina Radulovich,Amit Sharma,Johnny M. Tkach,Ming-Sound Tsao,Laurence Pelletier, Subhadip Mukhopadhyay, Subhadip Mukhopadhyay, Subhadip Mukhopadhyay
PloS oneno. 2 (2024): e0295030-e0295030
Cancer Researchno. 6_Supplement (2024): 217-217
JTO Clinical and Research Reportsno. 1 (2024): 100615-100615
Shiyan Wang, Yong Zeng, Lin Zhu, Min Zhang, Lei Zhou, Weixiong Yang, Weishan Luo, Lina Wang, Yanming Liu,Helen Zhu, Xin Xu,Peiran Su,
Cancer discovery (2024)
JTO CLINICAL AND RESEARCH REPORTSno. 1 (2024)
JTO Clinical and Research Reportspp.100682, (2024)
MODERN PATHOLOGYno. 1 (2024): 100384-100384
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Author Statistics
#Papers: 1186
#Citation: 74497
H-Index: 126
G-Index: 254
Sociability: 9
Diversity: 0
Activity: 8
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