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High-grade melanoma is characterized by chromosomal instability, invasive signature, DNA damage, Oxidative stress and a strong metabolism demand which contributes to transcriptional/epigenetic heterogeneity as well as post-translational modifications such as Ubiquitination which take part in protein homeostasis, necessary for survival and identity of cancer cells. I will concentrate on revealing molecular players involved in mechanisms that maintain protein homeostasis to cellular heterogeneity,
epigenetic regulation and metabolic demand renewal that underly melanoma plasticity, promoting metastasis and persisting resistance to treatment.
Mail: michael.ohanna@inserm.fr
Research Interests
Papers共 45 篇Author StatisticsCo-AuthorSimilar Experts
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Jessy Sirera, Saharnaz Sarlak, Manon Teisseire,Alexandrine Carminati,Coline Savy, Victoria J Nicolini,Patrick Brest, Thierry Juel,Christophe Bontoux,Marcel Deckert,Mickael Ohanna,Sandy Giuliano,
biorxiv(2024)
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Author Statistics
#Papers: 41
#Citation: 2118
H-Index: 20
G-Index: 41
Sociability: 5
Diversity: 0
Activity: 0
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