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职业迁徙
个人简介
Clinical Focus
Neurology
Neuro Oncology
Much of brain development occurs after birth. Maturation of complex neural circuitry necessary for high-level cognitive and motor functions occurs throughout childhood and young adulthood. Central to the process of developing or strengthening a functional neural circuit is the generation of new glial cells for neuronal support, synapse formation and myelination. In some brain regions, such as the hippocampus, new neuron production occurs throughout postnatal life and is believed to subserve normal memory function.
The Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states. Areas of emphasis include neuronal instruction of gliogenesis, cellular contributions to the neurogenic and gliogenic signaling microenvironment, molecular determinants of neural precursor cell fate, and the role of neural precursor cells in oncogenesis and repair mechanisms. As a practicing neurologist and Neuro-oncologist, Dr Monje is particularly interested in the roles for neural precursor cell function and dysfunction in the origins of pediatric brain tumors and the consequences of cancer treatment. As a paradigm of pediatric gliogenesis, we have been focusing on brainstem tumors, whose spatial and temporal specificity bespeak an underlying developmental cause.
Neurology
Neuro Oncology
Much of brain development occurs after birth. Maturation of complex neural circuitry necessary for high-level cognitive and motor functions occurs throughout childhood and young adulthood. Central to the process of developing or strengthening a functional neural circuit is the generation of new glial cells for neuronal support, synapse formation and myelination. In some brain regions, such as the hippocampus, new neuron production occurs throughout postnatal life and is believed to subserve normal memory function.
The Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states. Areas of emphasis include neuronal instruction of gliogenesis, cellular contributions to the neurogenic and gliogenic signaling microenvironment, molecular determinants of neural precursor cell fate, and the role of neural precursor cells in oncogenesis and repair mechanisms. As a practicing neurologist and Neuro-oncologist, Dr Monje is particularly interested in the roles for neural precursor cell function and dysfunction in the origins of pediatric brain tumors and the consequences of cancer treatment. As a paradigm of pediatric gliogenesis, we have been focusing on brainstem tumors, whose spatial and temporal specificity bespeak an underlying developmental cause.
研究兴趣
论文共 352 篇作者统计合作学者相似作者
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Natureno. 8017 (2024): 677-685
Neuromethods New Technologies for Glutamate Interactionpp.345-368, (2024)
Nature medicineno. 6 (2024): 1622-1635
Xu Zhang,Shoufu Duan, Panagiota E Apostolou,Xiaoping Wu,Jun Watanabe,Matthew Gallitto,Tara Barron,Kathryn R Taylor,Pamelyn J Woo,Xu Hua, Hui Zhou, Hong-Jian Wei,
Cancer discovery (2024)
Neuromethods New Technologies for Glutamate Interactionpp.301-312, (2024)
Yuan Pan,Michelle Monje
NATURE NEUROSCIENCE (2024)
Richard J. Gilbertson,Sam Behjati, Anna-Lisa Boettcher, Marianne E. Bronner, Matthew Burridge, Henrick Clausing, Harry Clifford, Tracey Danaher,Laura K. Donovan,Jarno Drost, Alexander M. M. Eggermont, Chris Emerson,
CANCER DISCOVERYno. 4 (2024): 663-668
Nature reviews. Disease primersno. 1 (2024): 33-33
Natureno. 8016 (2024): 457-465
Nature Reviews Disease Primersno. 1 (2024): 1-23
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