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T-cell recognition and sensitivity, cancer immunology, autoimmunity, receptor signaling, biophysics, cancer
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SUMMARY
The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to ‘self’ (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), biomembrane force probe X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches that can be applied to immunotherapy approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes). Supported by the Pew Trust, Cancer Research Institute (CRI), The Arthritis Foundation; New York Chapter, American Cancer Society (ACS), PS-ON/NCI/NIH and NIGMS/NIH.
KEYWORDS
T-cell recognition and sensitivity, cancer immunology, autoimmunity, receptor signaling, biophysics, cancer
Read Less
SUMMARY
The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to ‘self’ (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), biomembrane force probe X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches that can be applied to immunotherapy approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes). Supported by the Pew Trust, Cancer Research Institute (CRI), The Arthritis Foundation; New York Chapter, American Cancer Society (ACS), PS-ON/NCI/NIH and NIGMS/NIH.
研究兴趣
论文共 119 篇作者统计合作学者相似作者
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Ilya Kister,Ryan Curtin,Amanda L. Piquet,Tyler Borko,Jinglan Pei, Barbara L Banbury,Tamar E. Bacon, Angie Kim,Michael Tuen,Yogambigai Velmurugu,Samantha Nyovanie,Sean Selva,
medrxiv(2024)
Ilya Kister, Ryan Curtin,Amanda L Piquet,Tyler Borko,Jinglan Pei, Barbara L Banbury,Tamar E Bacon, Angie Kim,Michael Tuen,Yogambigai Velmurugu,Samantha Nyovanie,Sean Selva,
Annals of clinical and translational neurology (2024)
Milad Ibrahim,Irineu Illa-Bochaca, Faisal Fa'ak,Kelsey R. Monson,Robert Ferguson,Chen Lyu,Eleazar Vega-Saenz de Miera,Paul Johannet,Margaret Chou, Justin Mastroianni,Farbod Darvishian,Tomas Kirchhoff,
CANCERSno. 1 (2024): 18
Ilya Kister,Ryan Curtin,Jinglan Pei,Katherine Perdomo,Tamar. E. Bacon, Iryna Voloshyna,Joseph Kim, Ethan Tardio,Yogambigai Velmurugu,Samantha Nyovanie, Andrea Valeria Calderon, Fatoumatta Dibba,
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2023)
Nature Communicationsno. 1 (2023): 2616
引用7浏览0WOSNATURE引用
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Yury Patskovsky,Aswin Natarajan, Larysa Patskovska,Samantha Nyovanie,Bishnu Joshi,Benjamin Morin, Christine Brittsan, Olivia Huber,Samuel Gordon,Xavier Michelet,Florian Schmitzberger,Robert B. Stein,
Nature Communicationsno. 1 (2023): 4522-4522
Pankti Reid,Sabina Sandigursky,Juhee Song,Maria A. Lopez-Olivo, Houssein Safa,Samuel Cytryn,Elizaveta Efuni, Maryam Buni,Anna Pavlick,Michelle Krogsgaard,Osama Abu-Shawer, Mehmet Altan,
ONCOIMMUNOLOGYno. 1 (2023): 2261264-2261264
PEDIATRIC BLOOD & CANCER (2023): S181-S182
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crossref(2023)
Journal of Translational Medicineno. 1 (2023): 1-17
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