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Cellular and Physiologic Mechanisms Controlling Morphogenesis
Our laboratory is interested in studying how basic cellular processes define the shape and size of complex multicellular structures such as organs. Fluid movement into enclosed luminal or intracellular spaces creates hydrostatic pressure that can serve as a driving force for organogenesis and long range morphogenetic events such as axis elongation.
Our major goal to understand the role hydrostatic pressure plays as a developmental force. Using zebrafish we investigate:
1-The regulation of fluid secretion and the role of fluid pressure in organogenesis. Specifically, the mechanisms controlling the biogenesis and function of fluid-filled vacuoles in the notochord during embryogenesis and spine morphogenesis.
2-The role of the notochord in patterning the segmented vertebral column.
3-Cellular mechanisms controlling epithelial polarization and lumen formation in the gut tube.
Our laboratory is interested in studying how basic cellular processes define the shape and size of complex multicellular structures such as organs. Fluid movement into enclosed luminal or intracellular spaces creates hydrostatic pressure that can serve as a driving force for organogenesis and long range morphogenetic events such as axis elongation.
Our major goal to understand the role hydrostatic pressure plays as a developmental force. Using zebrafish we investigate:
1-The regulation of fluid secretion and the role of fluid pressure in organogenesis. Specifically, the mechanisms controlling the biogenesis and function of fluid-filled vacuoles in the notochord during embryogenesis and spine morphogenesis.
2-The role of the notochord in patterning the segmented vertebral column.
3-Cellular mechanisms controlling epithelial polarization and lumen formation in the gut tube.
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crossref(2024)
Nitya Ramkumar, Christian Richardson, Makinnon O'Brien, Faraz Ahmed Butt, Jieun Park,Anna T Chao,Michel Bagnat,Kenneth Poss,Stefano Di Talia
bioRxiv : the preprint server for biology (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Jia He,Adriana Blazeski, Uthayanan Nilanthi,Javier Menéndez, Samuel C Pirani,Daniel S Levic,Michel Bagnat,Manvendra K Singh, José G Raya,Guillermo García-Cardeña,Jesús Torres-Vázquez
bioRxiv : the preprint server for biology (2024)
Developmental Cell (2024)
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXI (2024)
CURRENT BIOLOGYno. 12 (2023): 2574-+
High-Speed Biomedical Imaging and Spectroscopy VIII (2023)
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