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The Welsh laboratory emphasizes research in two main areas. The first is understanding the biology of cystic fibrosis (CF), a common lethal genetic disease, and developing new treatments. Cystic fibrosis is caused by mutations in the gene that encodes the CFTR anion channel. Welsh and his colleagues are learning how the CFTR anion channel is regulated and how mutations disrupt its function. They also focus on the pathogenesis of cystic fibrosis lung disease, learning how the loss of CFTR causes the bacterial airway infections and inflammation that destroy the lung. To test key hypotheses, they developed a porcine model of cystic fibrosis that develops all the hallmarks of the human disease. Their studies of this model are providing a new understanding of the disease and are aiding the development of novel therapies. The lab also studies the molecular biology and physiology of changes in brain pH and the effect on acid sensing ion channels and neural function. They are particularly interested in understanding the bases of fear memory and how that memory might be altered to treat people with PTSD.
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论文共 621 篇作者统计合作学者相似作者
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Jordan L Schultz,Phillip E Gander,Craig D. Workman, Laura L Ponto,Stephen Cross, Christopher S. Nance, Christopher L. Groth,Eric B. Taylor,Sarah E. Ernst,Jia Xu,Ergun Y. Uc,Vincent Magnotta,
crossref(2024)
Hosung Bae,Bo Ram Kim,Sunhee Jung,Johnny Le,Dana M van der Heide,Wenjie Yu, Sang Hee Park,Brieanna M Hilkin, Nicholas D Gansemer,Linda S Powers, Taekyung Kang,David K Meyerholz,
The Journal of clinical investigation (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 9 (2024): e2318956121-e2318956121
Proceedings of the National Academy of Sciences of the United States of Americano. 10 (2024): e2318771121-e2318771121
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2024): 123693-123693
Journal of Cystic Fibrosis (2023): S107-S107
Proceedings of the National Academy of Sciences of the United States of Americano. 4 (2022)
Carley G. Stewart,Brieanna Hilkin,Nicholas D. Gansemer,Susan A. Walsh, Michael R. Acevado,Vamsidhar Akurathi,Darpan N. Pandya,Alejandro F. Comellas,Thaddeus J. Wadas,David W. Dick,John J. Sunderland,David A. Stoltz,
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