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职业迁徙
个人简介
He has extensive experience treating patients with blood cancers. He has a particular interest in chronic myeloid leukemia (CML) and myeloproliferative neoplasms, a group of blood cancers related to leukemia.
As a clinician-scientist trained in hematology/oncology as well as molecular biology I have been interested in the biology and therapy of leukemia and myeloproliferative neoplasms (MPNs) for more than 20 years. I have led an extramurally funded laboratory for 15 years and have assembled a team of researchers and technicians that provides an excellent training environment. Our technical expertise encompasses molecular and cellular biology, chemistry and chemical biology, murine leukemia models and ex vivo analysis of primary leukemia cells (we have established a substantial biorepository with >20,000 samples from >1,200 patients). We have made a number of contributions to our field of study that have influenced how leukemia and MPNs are diagnosed, treated and monitored. I have played an important role in multiple clinical studies in MPNs, including chronic myeloid leukemia (CML) that contributed to the establishment of tyrosine kinase inhibitor (TKI) - based therapies as the standard of care. Today our work continues, focusing on novel therapeutic targets in leukemia, novel drugs to overcome TKI resistance in CML and other MPNs, and to understand the role of bone marrow micro environment for leukemogenesis. Over the years I have trained and mentored a number of pre- and postdoctoral students and clinical fellows. Several of my trainees have secured faculty positions at major academic institutions in Europe or the US, and have attracted extramural funding to establish their own independent research groups. Having been involved in research for many years the success of my trainees has become a key measure of my own achievement. I profoundly enjoy the opportunity to get inspired by young investigators setting out to develop their research careers and I am determined to help them on their path to independence.
研究兴趣
论文共 869 篇作者统计合作学者相似作者
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GENOME RESEARCHno. 1 (2024): 94-105
Ho-Jae Han, Jaeyoon John Kim, Danielle Pyne, Anthea Travas, Amirthagowri Ambalavanan,Shinya Kimura,Michael W. Deininger,Jong-Won Kim,Dennis Dong Hwan Kim
Leukemiano. 2 (2024): 412-415
Bloodno. 23 (2023): 2797-2812
Meenu Kesarwani,Zachary Kincaid,Mohammad Azhar, Jacob Menke, Joshua Schwieterman,Sekhu Ansari, Angela Reaves,Michael E. Deininger,Ross Levine,H. Leighton Grimes,Mohammad Azam
Leukemiano. 8 (2023): 1686-1697
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Fieke W. Hoff, Ying Huang, Rina Li Welkie,Ronan T. Swords,Elie Traer,Eytan M. Stein,Tara L. Lin,Prapti A. Patel,Robert H. Collins,Maria R. Baer,Vu H. Duong,William Blum,
BLOOD (2023): 4296
Thomas O'Hare, Denise K. Walters,Eric P. Stoffregen,Taiping Jia,Paul W. Manley, Jürgen Mestan,Sandra W. Cowan-Jacob,Francis Y. Lee,Michael C. Heinrich,Michael W.N. Deininger,Brian J. Druker
crossref(2023)
HemaSphereno. S3 (2023): e88427a9-e88427a9
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Nataly Cruz-Rodriguez,Dongqing Yan, Briana Bates,Daniela Uribe-Cano, Tony Pomicter,Michael Deininger
BLOOD (2023): 41
Thomas O'Hare, Denise K. Walters,Eric P. Stoffregen,Taiping Jia,Paul W. Manley, Jürgen Mestan,Sandra W. Cowan-Jacob,Francis Y. Lee,Michael C. Heinrich,Michael W.N. Deininger,Brian J. Druker
crossref(2023)
crossref(2023)
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