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个人简介
As a practicing pediatric neurosurgeon/clinician scientist, my research focuses on using tools from human genetics/genomics, and from mouse models to better understand the biology of pediatric brain tumors, particularly medulloblastoma and ependymoma. As someone who is comfortable in both the clinic and at the bench, I have a great deal to offer in the development of translational research for brain tumor research. I have previously described a number of the genetic events that are thought to drive the pathogenesis of medulloblastoma. More recently my laboratory has developed functional genomic mouse models of medulloblastoma to help better interpret our genomic studies of human medulloblastoma. I am the creator, and principal investigator of the Medulloblastoma Advanced Genomics International Consortium (MAGIC), through which I have collected >2200 frozen medulloblastomas from >90 high quality pediatric neuro-oncology centers from around the world. My clinical expertise, research experience in the field, and my current resources uniquely position me to contribute to studies on medulloblastoma and ependymoma. My current research is heavily focused on the metastases of brain tumors, monitoring circulating tumor cells over time and the effects of current therapies and inflammatory responses on the metastatic process. The overall goal being to drive novel adjuvant therapies into the clinic to treat patients suffering from these devastating diseases.
研究兴趣
论文共 363 篇作者统计合作学者相似作者
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Linjie Zhao,Zhixin Qiu,Zhengnan Yang, Lian Xu,Thomas M. Pearce,Qiulian Wu, Kailin Yang,FuLong Li, Olivier Saulnier,Fan Fei, Huaxu Yu,Ryan C. Gimple,
Neuro-oncologyno. 5 (2024): 950-964
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