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Radiation, Free Radicals and DNA Damage
The Sevilla group’s research interests are the chemistry of free radical species produced by the high energy irradiation of DNA by gamma irradiation and ion beams. Both radiations are employed in treatment of cancer. Ion beams are increasingly of interest as they can be directed to the tumor and will stop in the tumor. The principal biological effect of radiation on a cell is caused by the direct interaction of radiation with DNA or molecules immediately surrounding the DNA which transmit the radiation damage to the DNA. Radiation induces ionizations, free electrons, excitations in DNA which decay to a variety of free radical intermediates. These reactive species create damages on DNA bases and the sugar phosphate backbone that may lead to cellular death or mutation.
The Sevilla group’s research interests are the chemistry of free radical species produced by the high energy irradiation of DNA by gamma irradiation and ion beams. Both radiations are employed in treatment of cancer. Ion beams are increasingly of interest as they can be directed to the tumor and will stop in the tumor. The principal biological effect of radiation on a cell is caused by the direct interaction of radiation with DNA or molecules immediately surrounding the DNA which transmit the radiation damage to the DNA. Radiation induces ionizations, free electrons, excitations in DNA which decay to a variety of free radical intermediates. These reactive species create damages on DNA bases and the sugar phosphate backbone that may lead to cellular death or mutation.
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The journal of physical chemistry. Bno. 17 (2024): 4053-4062
Daniel Adjei, Yahaira Reyes,Anil Kumar, Samuel Ward, Sergey A. Denisov, Moaadh Alahmadi,Michael D. Sevilla, Stanislaw F. Wnuk, Mehran Mostafavi,Amitava Adhikary
The Journal of Physical Chemistry Bno. 7 (2023): 1563-1571
Journal of Physical Chemistry Bno. 7 (2023): 1563-1571
DNA Damage, DNA Repair and DiseaseChemical Biology (2020): 426-457
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