基本信息
浏览量:1
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Michael Salsaa has utilized his extensive experience in molecular biology techniques and biochemical assays to study two major research questions. The first involves understanding the mechanism of action of a widely used bipolar medication (Valproate). Utilizing yeast, he uncovered various metabolic effects of the drug, most importantly of which is the activation of a major metabolic sensor, SNF1/AMPK. Additionally, this activation is most likely mediated through inositol-depletion, one of the major hypothesis proposed to explain the mechanism of action of several bipolar medications.
The second project involves the unique phospholipid, cardiolipin, the character molecule of mitochondrial inner membranes. Cardiolipin deletion results in major defects in mitochondrial metabolism (TCA cycle) and bioenergetics. Michael's work uncovered the importance of anaplerotic pathways that feed into the TCA cycle when cardiolipin is absent. When cardiolipin is absent, these pathways become essential for survival of yeast cells to support basic metabolic and energy needs.
Michael's work has resulted in $1.25 M in grant funding and the creation of 3 additional research projects. He is currently a consultant on 5 research projects and has extensively trained 9 graduate/undergraduate students and helped in enhancing their critical thinking skills, project management abilities, and pragmatic research strategies.
Michael embraces diverse environments and is committed to promoting creativity, effective problem solving, and breakthrough results. Specializing in cross-functional team leadership with a focus on delivering positive outcomes within given timelines. Throughout his academic career, he has been an active part and co-leader of multiple grass loot level movements involved in raising a voice and providing solutions for the overall betterment of the community.
Distinctively specialized in metabolic analysis, his competencies include Flow Cytometry, NMR Spectroscopy, Quantitative real-time PCR (qPCR), Mass Spectrometry, Polymerase chain reaction (PCR), DNA/RNA Isolation/Purification, Western Blotting, In Vitro Functional Assays, Fluorescence Microscopy, Classical/Molecular Genetics of Yeast, statistical Analysis in Excel and GraphPad Prism, Mammalian Cell Culture and Transfection.
研究兴趣
论文共 8 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
The Journal of biological chemistryno. 4 (2021): 101110-101110
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn