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Recent work in our laboratory and elsewhere has highlighted additional properties of antigen receptor loci that likely to play important roles in developmental regulation. One area of interest is subnuclear positioning. We have used three-dimensional fluorescence in situ hybridization (3D-FISH) to show that TCRβ alleles interact stochastically and at high frequency with the nuclear lamina and with foci of pericentromeric heterochromatin, and that these interactions are inhibitory to V(D)J recombination. We suspect that these inhibitory interactions help to promote allelic exclusion by diminishing the likelihood of simultaneous V to DJ recombination on both alleles. Current work is aimed at developing a better understanding of how the TCRβ locus interacts with the nuclear lamina and the mechanism by which this interaction impacts recombination events.
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Abani Kanta Naik,Danielle J Dauphars, Elizabeth Corbett, Lunden Simpson,David G Schatz,Michael S Krangel
Science immunologyno. 93 (2024): eadh5318-eadh5318
Abani Kanta Naik,Danielle J. Dauphars, Elizabeth Corbett, Lunden Simpson, David G. Schatz,Michael S. Krangel
SCIENCE IMMUNOLOGYno. 93 (2024)
Frontiers in immunology (2023): 1188738
The Journal of experimental medicineno. 9 (2020)
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