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Ubiquitin-dependent control of cell fate decisions
Our laboratory is interested in understanding the molecular mechanisms of cell fate decisions during metazoan development. While our early work focused on deciphering principles of regulated cell cycle transitions, we have recently begun to dissect signaling pathways that direct the differentiation of human embryonic stem cells. In our studies, we are paying particular attention to the function of a posttranslational modification, ubiquitylation, that is essential for human development and whose misregulation causes a wide range of devastating diseases. In particular, we identify ubiquitylation enzymes and their substrates that govern cell fate decisions; determine molecular mechanisms by which ubiquitin drives cell fate decisions; and develop novel therapeutic strategies to modulate pathological cell fate decisions, with an emphasis on cancer or pediatric diseases.
Ubiquitin-dependent control of cell fate decisions
Our laboratory is interested in understanding the molecular mechanisms of cell fate decisions during metazoan development. While our early work focused on deciphering principles of regulated cell cycle transitions, we have recently begun to dissect signaling pathways that direct the differentiation of human embryonic stem cells. In our studies, we are paying particular attention to the function of a posttranslational modification, ubiquitylation, that is essential for human development and whose misregulation causes a wide range of devastating diseases. In particular, we identify ubiquitylation enzymes and their substrates that govern cell fate decisions; determine molecular mechanisms by which ubiquitin drives cell fate decisions; and develop novel therapeutic strategies to modulate pathological cell fate decisions, with an emphasis on cancer or pediatric diseases.
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论文共 140 篇作者统计合作学者相似作者
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Diane L. Haakonsen, Michael Heider, Andrew J. Ingersoll, Kayla Vodehnal, Samuel R. Witus,Takeshi Uenaka,Marius Wernig,Michael Rapé
Journal of the American Chemical Societyno. 38 (2023): 21142-21142
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 38 (2023): 21142-21142
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Trends in biochemical sciencesno. 5 (2023): 407-409
CELLno. 16 (2023): 3460-3475
Molecular cellno. 8 (2022): 1439-1450
Trends in biochemical sciencesno. 9 (2022): 759-771
Celine Perier,Emmanuel Nasinghe, Isabelle Charles,Leoson Junior Ssetaba,Vida Ahyong,Derek Bangs, P Robert Beatty,Nadine Czudnochowski, Amy Diallo,Eli Dugan,Jacqueline M Fabius, Hildy Fong Baker,
Andrew G Manford,Elijah L Mena,Karen Y Shih,Christine L Gee, Rachael McMinimy,Brenda Martínez-González,Rumi Sherriff,Brandon Lew,Madeline Zoltek,Fernando Rodríguez-Pérez, Makda Woldesenbet,John Kuriyan,
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