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Research:
Stress and pain-induced behavior is controlled by specific neurotransmitters and their signaling partners in the central and peripheral nervous systems. Many of these signals are conveyed through activation of neuropeptide and monoamine receptor systems. These receptors are seven transmembrane spanning G-protein coupled receptors (GPCR, also called 7 transmembrane receptors) and they engage a variety of signaling cascades following neurotransmitter release and receptor binding. To expand our knowledge of the inner workings of the brain and to identify treatments for psychiatric diseases, the Bruchas laboratory aims to dissect how GPCR systems function in the contexts of stress, depression, addiction, and pain. We strive for a greater understanding of these receptors in real time, within intact systems, and biologically relevant models of behavior. We utilize pharmacological, optogenetic, genetic, viral, imaging, behavioral, and cutting-edge engineering approaches to uncover the specific role of GPCRs and their endogenous transmitters within in vivo neural circuits that modulate affective behavior.
Stress and pain-induced behavior is controlled by specific neurotransmitters and their signaling partners in the central and peripheral nervous systems. Many of these signals are conveyed through activation of neuropeptide and monoamine receptor systems. These receptors are seven transmembrane spanning G-protein coupled receptors (GPCR, also called 7 transmembrane receptors) and they engage a variety of signaling cascades following neurotransmitter release and receptor binding. To expand our knowledge of the inner workings of the brain and to identify treatments for psychiatric diseases, the Bruchas laboratory aims to dissect how GPCR systems function in the contexts of stress, depression, addiction, and pain. We strive for a greater understanding of these receptors in real time, within intact systems, and biologically relevant models of behavior. We utilize pharmacological, optogenetic, genetic, viral, imaging, behavioral, and cutting-edge engineering approaches to uncover the specific role of GPCRs and their endogenous transmitters within in vivo neural circuits that modulate affective behavior.
Research Interests
Papers共 257 篇Author StatisticsCo-AuthorSimilar Experts
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Justin Daho Lee,Woojin Won, Kandace Kimball, Yihan Wang, Fred Yeboah,Kira M. Evitts, Carlie Neiswanger,Selena Schattauer,Michael Rappleye,Samantha B Bremner,Changho Chun,Netta Smith,
crossref(2024)
bioRxiv : the preprint server for biology (2024)
Justin Daho Lee,Woojin Won, Kandace Kimball,Yihan Wang,Fred Yeboah,Kira M. Evitts, Carlie Neiswanger,Selena Schattauer,Michael Rappleye,Samantha B Bremner,Changho Chun,Netta Smith,
bioRxiv the preprint server for biology (2024)
Sarah Thai, Sean Piantidosi,Madison Martin, Veronica Porubsky,Avi Matarasso,Selena Schattauer,Tammy Nguyen,Larry Zweifel,Michael Bruchas
Sean C Piantadosi,Min-Kyu Lee,Mingzheng Wu, Huong Huynh,Raudel Avila,Carina Pizzano,Catalina A Zamorano,Yixin Wu, Rachael Xavier, Maria Stanslaski, Jiheon Kang, Sarah Thai,
bioRxiv : the preprint server for biology (2024)
Anthony English, Fleur Uittenbogaard,Alexa Torrens,Dennis Sarroza, Anna Veronica Elizabeth Slaven,Daniele Piomelli,Michael R. Bruchas,Nephi Stella,Benjamin Bruce Land
ELIFE (2024)
Neurophotonicsno. 03 (2024)
Chunyang Dong,Raajaram Gowrishankar, Yihan Jin, Xinyi Jenny He,Achla Gupta,Huikun Wang, Nilüfer Sayar-Atasoy, Rodolfo J Flores, Karan Mahe,Nikki Tjahjono,Ruqiang Liang, Aaron Marley,
Nature neuroscience (2024)
Emily Hueske, Carrie Stine,Tomoko Yoshida,Jill R Crittenden, Akshay Gupta, Joseph C Johnson, Ananya S Achanta, Johnny Loftus, Ara Mahar, Dan Hul, Jesus Azocar, Ryan J Gray,
bioRxiv : the preprint server for biology (2024)
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