Michael J Overman

基本信息

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职业迁徙

个人简介

I am a clinical trialist and translational research focused upon pancreatic and intestinal cancers. I have an extended focus on the rare tumor type of small bowel adenocarcinoma where we have molecularly characterized this cancer and developed model systems for study. I am principal investigator on a number of clinical trials investigating immune-checkpoint therapy in gastrointestinal malignancies. I have ongoing efforts to investigate the role of stromal modulation to enhance the activity of immune-checkpoint therapy.

研究兴趣

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Defining the Subset of Mutations in Polymerase Epsilon (POLE) Associated with Loss-of-Proofreading (LOP) Functionality

G. Maddalena,F.A. Zeineddine,S. Rivero-Hinojosa,V.N. Aushev, S. Chowdhury,M.A. Zeineddine, A.M. Yousef,T.A. Yap, A.C. EINaggar, M.C. Liu, M. White,M.J. Overman,

Annals of oncology official journal of the European Society for Medical Oncologyno. 7 (2024): 678-680

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Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Nicholas J Hornstein,Mohammad A Zeineddine,Betul B Gunes,Andrew J Pellatt,Mark Knafl,Haifeng Zhu,Anneleis F Willett,Abdelrahman Yousef,Suyu Liu,Ryan Sun,Andrew Futreal,Scott E Woodman,

Cancer research communicationsno. 5 (2024): 1363-1368

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A phase II trial of TAS-102 in patients with colorectal cancer with ctDNA-defined minimal residual disease post-adjuvant therapy compared to synthetic control cohort: Results from the MD Anderson INTERCEPT program

Andrew Jared Pellatt, Giulia Maddalena,Alisha Heather Bent,Christine Megerdichian Parseghian,Ryan W Huey,Kanwal Pratap Singh Raghav,Van K. Morris,Michael J. Overman,Maria Pia Morelli,Jason Willis,Phat Le,John Paul Y.C. Shen,

Journal of Clinical Oncologyno. 16_suppl (2024): 3623-3623

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Efficacy and Safety of Autologous Tumor-Infiltrating Lymphocytes in Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, and Pancreatic Ductal Adenocarcinoma

Rodabe Amaria,Anne Knisely,David Vining,Scott Kopetz,Michael J. Overman,Milind Javle,Mara B. Antonoff,Ching-Wei D. Tzeng,Robert A. Wolff,Shubham Pant,Kathryn Lito,Kelly Rangel,

Journal for immunotherapy of cancerno. 2 (2024): e006822-e006822

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Comprehensive Landscape of BRAF Variant Classes, Clonalities, and Co-Mutations in Metastatic Colorectal Cancer Using ctDNA Profiling

Benny Johnson,Van Morris,Xuemei Wang,Arvind Dasari,Kanwal Raghav,John Paul Shen,Michael S. Lee,Ryan Huey,Christine Parseghian,Jason Willis,Robert Wolff,Leylah M. Drusbosky,

CANCERSno. 4 (2024): 737

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Supplementary Tables from Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Nicholas J. Hornstein,Mohammad A. Zeineddine,Betul B. Gunes,Andrew J. Pellatt,Mark Knafl,Haifeng Zhu,Anneleis F. Willett,Abdelrahman Yousef,Suyu Liu,Ryan Sun,Andrew Futreal,Scott E. Woodman,

crossref（2024）

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Racial/ethnic representation and disparities in preclinical cancer models

Jonathan M. Loree,Arvind Dasari,Jason Willis, Himanish Gothwal, Mena Shaheed, Kulwinder Singh, Hewad Shaheed, Riya Mangal, Shivek Gothwal, Anya Pant,Michael J. Overman,Scott Kopetz,

Journal of Clinical Oncologyno. 16_suppl (2024): 1601-1601

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iExplore: A phase I study of mesenchymal stem cell derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring the KrasG12D mutation