Prof. Olson’s research has been directed at three levels: understanding the fundamental molecular mechanisms by which Rho GTPases contribute to the regulation of proliferation, cell division and apoptosis/survival; creating mouse models to determine how Rho signalling promotes tumourigenesis and growth in vivo and for testing Rho signalling inhibitors as potential chemotherapeutic agents; initiating and driving drug discovery efforts that will lead to the development of novel inhibitors of Rho signalling pathway components.