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个人简介
Our research group applies Raman spectroscopy and spectroscopically resolved two and three dimensional imaging to chemical and biomedical problems. It also specializes in high speed video microscopy. We are interested in problems at scales ranging from single molecules to tissue specimens.
We are leaders in Raman microspectroscopy and microscopic imaging. We develop new spectroscopic instrumentation based on modern photonics technology and new chemometric and other image processing methods for generation of hyperspectral image contrast. A core interest is the chemistry that governs the properties of musculo-skeletal tissues. We use our unique Raman spectroscopic imaging and dynamic microspectroscopy capabilities to study normal and pathological development and failure mechanisms of these tissues at every stage of the life cycle from embryo through maturity. We study how these tissues change over time and how they respond to the imposition of normal and traumatic external loads. The work has led to new insights into the effects of skeletal birth defects such as craniosynotosis and osteogenesis imperfecta, into the tissue changes associated with metababolic diseases such as osteoporosis and osteoarthritis and into the biomechanics of bone tissue and cartilage. The same technology is also applied to characterization of biomaterials ranging from heart valve replacements to dental cements.
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Mark Bradley, Iván Martín, Anke J. Roelofs,Sundeep Khosla,Sumeet Mahajan, Markus O. Heller,Philipp Schneider,Lynda F. Bonewald,Karen A. Lillycrop, Mark A. Hanson,Janet M. Lord, Steven R. Cummings,
JBMR plusno. S1 (2018)
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