基本信息
views: 57
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Dr. McClelland and members of his laboratory use genomics to approach two general research areas.
First, we study dys-regulation of genes that occurs in cancer. We were the first to describe that the regulatory regions of mammalian genes, called promoters, contain sequences called CpG islands. Methylation of these features is important in marking genes for regulation. We constructed the first “promoter microarrays” of DNA fragments from 10,000 promoters and collaborated on the first Chromatin immunoprecipitation-array (ChIP-chip) experiments, which identify proteins bound to promoters in living cells. The McClelland lab is particularly interested in alterations of gene expression in adjacent normal tissue during cancer progression. As part of this work, we are involved in a large multi-center grant to identify changes in gene expression in prostate cancer that are associated with increased risk of recurrence of the disease after prostatectomy.
Research Interests
Papers共 515 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Science (New York, N.Y.)no. 6691 (2024): 100-105
Vinay Kumar, Dominic Castaneda,James A. Nguyen, Giovanna A. Giannico,Michael M. Ittmann,Patricia Castro,Omid Yazdanpanah,Arash Rezazadeh, Tara S. Jennings,Michael Mcclelland,Farah Rahmatpanah
Cancer Researchno. 6_Supplement (2024): 2150-2150
FRONTIERS IN PLANT SCIENCE (2024): 1302047-1302047
microLife (2024): uqae003-uqae003
John J. Maurer,Ying Cheng,Adriana Pedroso, Kasey K. Thompson, Shamima Akter,Tiffany Kwan,Gota Morota, Sydney Kinstler,Steffen Porwollik,Michael Mcclelland,Jorge C. Escalante-Semerena,Margie D. Lee
Cell host & microbeno. 3 (2024): 411-424.e10
Jessica A Klein,Alexander V Predeus, Aimee R Greissl, Mattie M Clark-Herrera, Eddy Cruz,Jennifer A Cundiff,Amanda L Haeberle, Maya Howell, Aaditi Lele, Donna J Robinson, Trina L Westerman, Marie Wrande,
bioRxiv : the preprint server for biology (2024)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn