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TOR is a major controller of cell growth
TOR (Target of Rapamycin) is a conserved protein kinase that controls a wide range of metabolic processes. More importantly, TOR is a central controller of cell growth that plays a key role in development and ageing. TOR is implicated in many disorders including cancer, cardiovascular disease, diabetes, and obesity. The aim of our research is to elucidate the mechanisms by which TOR is regulated and in turn how it controls its many processes in both health and disease.
Investigating TOR signaling in human tumors
We study TOR signaling and growth control in the yeast Saccharomyces cerevisiae, in mammalian cells, in mice and in human tumors using biochemical, genetic and cell biological approaches. The work with human tumors is a translational research project that relies on close collaborations with clinicians.
New therapeutic strategies
Cell division, growth and death are the most fundamental features of life. Our studies contribute to understanding the important process of cell growth. Understanding mammalian TOR (mTOR) signaling and how it is dysregulated in disease may reveal new therapeutic strategies for a wide variety of disorders.
TOR (Target of Rapamycin) is a conserved protein kinase that controls a wide range of metabolic processes. More importantly, TOR is a central controller of cell growth that plays a key role in development and ageing. TOR is implicated in many disorders including cancer, cardiovascular disease, diabetes, and obesity. The aim of our research is to elucidate the mechanisms by which TOR is regulated and in turn how it controls its many processes in both health and disease.
Investigating TOR signaling in human tumors
We study TOR signaling and growth control in the yeast Saccharomyces cerevisiae, in mammalian cells, in mice and in human tumors using biochemical, genetic and cell biological approaches. The work with human tumors is a translational research project that relies on close collaborations with clinicians.
New therapeutic strategies
Cell division, growth and death are the most fundamental features of life. Our studies contribute to understanding the important process of cell growth. Understanding mammalian TOR (mTOR) signaling and how it is dysregulated in disease may reveal new therapeutic strategies for a wide variety of disorders.
Research Interests
Papers共 801 篇Author StatisticsCo-AuthorSimilar Experts
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Elsevier eBookspp.413-426, (2024)
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Handbook of Obesity, Two-Volume Setpp.469-480, (2024)
Tariq Jamal Siddiqi,Muhammad Shariq Usman, Amna Siddiqui,Ali Salman, Nicholas Talbot, Laibah Arshad Khan, Aisha Shabbir,Michael E. Hall,George E. Taffet
CURRENT PROBLEMS IN CARDIOLOGYno. 1 (2024): 102131-102131
Marios K Georgakis,Rainer Malik,Omar El Bounkari,Natalie R Hasbani,Jiang Li,Jennifer E Huffman,Gabrielle Shakt, Reinier W P Tack, Tamara N Kimball,Yaw Asare,Alanna C Morrison,Noah L Tsao,
EUROPEAN JOURNAL OF HEART FAILUREno. 1 (2024): 103-106
The International Journal of Cardiovascular Imagingpp.1-8, (2024)
Hunter Mace, Nathan Foxworth,Affan Rizwan,Arsalan Hamid,William F. Campbell,Michael R. McMullan,Michael E. Hall
Journal of the American College of Cardiologyno. 13 (2024): 1660
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGYno. 6 (2024): 649-651
Caseem C. Luck,Sarah Bauerle Bass,Yana Chertock, Patrick J. A. Kelly, Katie Singley,Ariel Hoadley,Michael J. Hall
JOURNAL OF COMMUNITY GENETICS (2024)
CANCER RESEARCH COMMUNICATIONSno. 1 (2024): 213-225
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