基本信息
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个人简介
My Research
KEYWORDS
signal transduction and transcriptional regulation by nuclear receptors, molecular, cellular, & translational neuroscience, regulation of atherosclerosis by LXR, targeting therapy resistant prostate cancer
SUMMARY
Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. The focus of my laboratory is to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer. We use state-of-the-art genetic (mouse knock-outs and knock-ins and CRISPR-Cas9 gene editing), biochemical (RNA-/ ChIP-seq and high-throughput siRNA and small molecules screens) as well as proteomic strategies to identify macromolecular complexes important in nuclear receptor activity to elucidate the mechanism of LXR, AR and GR function in vivo. Characterizing factors that control nuclear receptor activity can lead to potential new therapeutic strategies for prostate cancer, atherosclerosis as well as stress related anxiety, and depression.
KEYWORDS
signal transduction and transcriptional regulation by nuclear receptors, molecular, cellular, & translational neuroscience, regulation of atherosclerosis by LXR, targeting therapy resistant prostate cancer
SUMMARY
Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. The focus of my laboratory is to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer. We use state-of-the-art genetic (mouse knock-outs and knock-ins and CRISPR-Cas9 gene editing), biochemical (RNA-/ ChIP-seq and high-throughput siRNA and small molecules screens) as well as proteomic strategies to identify macromolecular complexes important in nuclear receptor activity to elucidate the mechanism of LXR, AR and GR function in vivo. Characterizing factors that control nuclear receptor activity can lead to potential new therapeutic strategies for prostate cancer, atherosclerosis as well as stress related anxiety, and depression.
研究兴趣
论文共 167 篇作者统计合作学者相似作者
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ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGYno. 1 (2024): 87-96
Cancer Researchno. 7_Supplement (2023): 3441-3441
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Justine Habault, Jeffrey A. Schneider,Susan Ha,Rachel Ruoff, Luiza D. Pereira, Joseph Puccini,Michela Ranieri,Ruveyda Ayasun,Jiehui Deng,Amanda C. Kasper,Dafna Bar-Sagi,Kwok-Kin Wong,
crossref(2023)
crossref(2023)
Natalie E. Simpson,W. Marcus Lambert, Renecia Watkins,Shah Giashuddin, S. Joseph Huang, Ellinor Oxelmark, Rezina Arju, Tsivia Hochman,Judith D. Goldberg,Robert J. Schneider, Luiz Fernando Lima Reiz,Fernando Augusto Soares,
crossref(2023)
Justine Habault, Jeffrey A. Schneider,Susan Ha,Rachel Ruoff, Luiza D. Pereira, Joseph Puccini,Michela Ranieri,Ruveyda Ayasun,Jiehui Deng,Amanda C. Kasper,Dafna Bar-Sagi,Kwok-Kin Wong,
crossref(2023)
Justine Habault,Jeffrey A Schneider, Susan Ha, Rachel Ruoff, Luiza D Pereira,Joseph Puccini, Michela Ranieri, Ruveyda Ayasun,Jiehui Deng,Amanda C Kasper, Dafna Bar-Sagi,Kwok-Kin Wong,
Molecular cancer therapeuticsno. 10 (2023): 1166-1181
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