基本信息
views: 5
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My research revolves around natural products, their chemical diversity, structural analysis, and potential therapeutic value. Currently, my focus lies on small molecular weight, hydroxamic acid based Fe(III)-chelating compounds, known as siderophores, and their application in diseases with Fe dyshomeostasis. In our lab, we are investigating the many faces of one such chelator, the clinically used desferrioxamine B (DFOB) and I’m interested in its application in Parkinson’s disease (PD). PD is characterised by the loss of dopaminergic neurons in the substantia nigra region of the brain. This neuronal loss is partially attributed to oxidative stress, which is exacerbated by the pathological presence of excess iron in the substantia nigra. Through semi-synthetically creating lipophilic DFOB variants, we aim to sequester excess iron and minimise its redox potential, which is considered of therapeutic value. Our collaborators at the Florey Institute in Melbourne have and are testing our compounds in a PD mouse model.
Research Interests
Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
ChemBioChemno. 10 (2020): 1384-1384
BioMetalsno. 3 (2019): 395-408
Load More
Author Statistics
#Papers: 19
#Citation: 246
H-Index: 9
G-Index: 15
Sociability: 4
Diversity: 1
Activity: 0
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn