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Dr. Carey studies biochemical mechanisms of gene activation and silencing. In 1990, Dr. Carey established biochemical systems for studying gene regulation based on a model transcriptional activator termed GAL4-VP16. Using that system, Dr. Carey established a mechanism by which genes are controlled synergistically by upstream activators. Synergy is a key principle in gene regulation and underlies the combinatorial control of gene transcription. Throughout the 1990s, Dr. Carey’s lab showed that synergy is first manifested during assembly of transcription preinitiation complexes (PICs). His lab identified assembly of a co-activator complex, termed DAMed, as the key step influenced by activators. More recently, Dr. Carey has been studying the biochemistry of transcription on chromatin templates after a one year sabbatical at the Stowers Institute for Medical Research in 2006. Dr. Carey’s lab has shown how a protein termed p300 coordinates chromatin modification with assembly of the DAMed complex and then the PIC. His lab has also shown how a protein termed HP1 silences transcription by selectively affecting key components of the DAMed complex. Dr. Carey’s recent work has focused on recreating the effects of histone methylation on gene activation and silencing in vitro.
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论文共 200 篇作者统计合作学者相似作者
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An-Chieh Feng,Brandon J Thomas, Prabhat K Purbey, Filipe Menegatti de Melo,Xin Liu, Allison E Daly,Fei Sun, Jerry Hung-Hao Lo,Lijing Cheng,Michael F Carey,Philip O Scumpia,Stephen T Smale
Immunityno. 3 (2024): 462-477.e9
Mohammad Nazim,Chia-Ho Lin,An-Chieh Feng, Wen Xiao,Kyu-Hyeon Yeom, Mulin Li, Allison E. Daly, Xianglong Tan,Ha Vu,Jason Ernst,Michael F. Carey,Stephen T. Smale,
Cell Stem Cellno. 5 (2024): 754-771.e6
Cell reportsno. 10 (2020): 108106-108106
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