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Michael B. Yaffe studies the chain of reactions that controls a cell’s response to stress, cell injury, and DNA damage.
Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.
Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.
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Elsevier eBookspp.31-56, (2024)
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Alex Kruswick,Bert van de Kooij,Tiffany R. Emmons,Ganapathy Sriram, Emma D. Martin, Anjali Arvind,Haico van Attikum,Michael B. Yaffe
CANCER RESEARCHno. 1 (2024)
Surajit Sinha,Abir Panda,Zeribe Nwosu, Rodrigo Neves Das,Xu Ke, Elke van Beek, Alexander J. Rossi,Reed I. Ayabe,James McDonald,Michael M. Wach,Samantha Ruff, Priyanka P. Desai,
CANCER RESEARCHno. 2 (2024)
bioRxiv : the preprint server for biology (2023)
Tatiana S. Netterfield,Gerard J. Ostheimer,Andrea R. Tentner,Brian A. Joughin, Alexandra M. Dakoyannis, Charvi D. Sharma,Peter K. Sorger,Kevin A. Janes,Douglas A. Lauffenburger,Michael B. Yaffe
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