基本信息
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Bio
Michael B. Yaffe studies the chain of reactions that controls a cell’s response to stress, cell injury, and DNA damage.
Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.
Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.
Research Interests
Papers共 484 篇Author StatisticsCo-AuthorSimilar Experts
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Bert van de Kooij, Fenna J van der Wal,Magdalena B Rother,Wouter W Wiegant,Pau Creixell, Merula Stout,Brian A Joughin, Julia Vornberger, Matthias Altmeyer, Marcel A T M van Vugt,Michael B Yaffe,Haico van Attikum
Nature communicationsno. 1 (2024): 7076-7076
Christopher D. Barrett,Peter K. Moore,Ernest E. Moore,Hunter B. Moore,James G. Chandler, Halima Siddiqui,Elizabeth R. Maginot,Angela Sauaia,Angel Augusto Pérez-Calatayud,Keely Buesing, Jiashan Wang, Cesar Davila-Chapa,
CHEST (2024)
Tracey Pu,Steven Forsythe, Priyanka Desai,Brian A. Joughin,Ronald Holewinski, Thorkell Andrid, Carolina Larrain, Jack Victory,Amber Leila Sarvestani,Yuri Lin,Sarfraz R. Akmal,Suresh Kumar,
ANNALS OF SURGICAL ONCOLOGYno. 1 (2024): S20-S20
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Elsevier eBookspp.31-56, (2024)
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Alex Kruswick,Bert van de Kooij,Tiffany R. Emmons,Ganapathy Sriram, Emma D. Martin, Anjali Arvind,Haico van Attikum,Michael B. Yaffe
CANCER RESEARCHno. 1 (2024)
Yi Wen Kong,Erika D. Handly, Robin A. Lu,Molly A. Bird, Hannah-Lou Schilling, Samkyu P. Yaffe,Michael B. Yaffe, David H. Koch
CANCER RESEARCHno. 5 (2024)
NATUREno. 8014 (2024): 1-8
Surajit Sinha,Abir Panda,Zeribe Nwosu, Rodrigo Neves Das, Xu Ke,Elke van Beek,Alexander J. Rossi,Reed I. Ayabe,James McDonald,Michael M. Wach,Samantha Ruff, Priyanka P. Desai,
CANCER RESEARCHno. 2 (2024)
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Author Statistics
#Papers: 485
#Citation: 50217
H-Index: 108
G-Index: 221
Sociability: 8
Diversity: 3
Activity: 90
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