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个人简介
I pioneered the field of viral immunology and have been a leader in viral pathogenesis and immunity for the past four decades. I am known for my work studying the interaction of the arenavirus lymphocytic choriomeningitis virus with its natural murine host as well as investigations of measles virus. My observations indicated how viruses induce suppression of the immune system to cause a persistent infection and how viruses activate the immune system to cause autoimmunity. I have defined the parameters of the formation and consequences of virus-antiviral antibody immune complex deposits leading to disease, host molecules like IL-10 that the virus induces to suppress the immune system and the description and consequences of how a persistent virus infects differentiated cells, alters their function, disturbs homeostasis and cause disease.
研究兴趣
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Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
Cancer Researchno. 7_Supplement (2023): 5743-5743
Proceedings of the National Academy of Sciences of the United States of Americano. 3 (2022)
Viruses, Plagues, and Historypp.23-34, (2020)
EMBO molecular medicineno. 1 (2020): e13533-e13533
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