基本信息
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Bio
Honors & Awards
Early Career Life Scientist Award of the American Society for Cell Biology
Edith and Peter O’Donnell Award in Medicine
Glenn Award for Research in Biological Mechanisms of Aging
NIH Director’s Pioneer Award
Howard Hughes Medical Institute Faculty Scholars Award
Marc Dresden Excellence in Graduate Education Award
Gibco Emerging Leader Prizes of the American Society for Cell Biology
Ellison Medical Foundation New Scholar Award
Michael E. DeBakey M.D. Excellence in Research Award
AAAS Fellow
American Association for the Advancement of Science. (11/2019)
Professional Interests
Systemic studies of endocrine and metabolic signaling in promoting healthy aging
Professional Statement
Our research goals are to advance our knowledge on the fundamental mechanisms of somatic aging, lipid metabolism and reproductive senescence. These intertwined biological processes exert profound influence on human health, and are the major risk factors for various chronic and degenerative diseases. Our laboratory has been studying the molecular mechanisms governing these key biological processes and their complex interrelationship, by harnessing the power of functional genomics in Caenorhabditis elegans with metabolomics/lipodomics, chemical engineering and optical biophysics.
Our research has uncovered a lysosome-to-nucleus retrograde lipid messenger pathway, provided in-depth biochemical mechanisms for its action, and demonstrated its novel roles in regulating longevity. We have also discovered a previously unknown communication mode between bacteria and host mitochondria, deciphered bacteria-derived metabolites mediating this ancient dialogue and their signaling mechanisms, and determined their vital effects on host’s lipid metabolism and longevity. In addition, our work provides evidences that volatile metabolites signal through specific olfactory neuroendocrine nexus to shape reproductive and metabolic strategies. Technically, we have developed and applied hyperspectral and isotope-labeling-coupled stimulated Raman scattering (SRS) microscopy systems for investigating in vivo spatiotemporal dynamics of metabolite molecules and its previously unknown association with metabolic pathologies. Based on SRS microscopy, we have assembled high-throughput platforms for both forward and reverse genetic screens, leading to the discovery of new regulatory mechanisms of lipid metabolism.
Ongoing projects in my laboratory include: (1) investigating the systemic role of lipid signaling in the regulation of longevity; (2) studying the mechanistic link governing the signaling crosstalk between bacteria and host mitochondria; (3) characterizing the cellular and molecular mechanism regulating reproductive homeostasis during aging; (4) analyzing lipid dynamics using quantitative SRS label-free imaging.
Early Career Life Scientist Award of the American Society for Cell Biology
Edith and Peter O’Donnell Award in Medicine
Glenn Award for Research in Biological Mechanisms of Aging
NIH Director’s Pioneer Award
Howard Hughes Medical Institute Faculty Scholars Award
Marc Dresden Excellence in Graduate Education Award
Gibco Emerging Leader Prizes of the American Society for Cell Biology
Ellison Medical Foundation New Scholar Award
Michael E. DeBakey M.D. Excellence in Research Award
AAAS Fellow
American Association for the Advancement of Science. (11/2019)
Professional Interests
Systemic studies of endocrine and metabolic signaling in promoting healthy aging
Professional Statement
Our research goals are to advance our knowledge on the fundamental mechanisms of somatic aging, lipid metabolism and reproductive senescence. These intertwined biological processes exert profound influence on human health, and are the major risk factors for various chronic and degenerative diseases. Our laboratory has been studying the molecular mechanisms governing these key biological processes and their complex interrelationship, by harnessing the power of functional genomics in Caenorhabditis elegans with metabolomics/lipodomics, chemical engineering and optical biophysics.
Our research has uncovered a lysosome-to-nucleus retrograde lipid messenger pathway, provided in-depth biochemical mechanisms for its action, and demonstrated its novel roles in regulating longevity. We have also discovered a previously unknown communication mode between bacteria and host mitochondria, deciphered bacteria-derived metabolites mediating this ancient dialogue and their signaling mechanisms, and determined their vital effects on host’s lipid metabolism and longevity. In addition, our work provides evidences that volatile metabolites signal through specific olfactory neuroendocrine nexus to shape reproductive and metabolic strategies. Technically, we have developed and applied hyperspectral and isotope-labeling-coupled stimulated Raman scattering (SRS) microscopy systems for investigating in vivo spatiotemporal dynamics of metabolite molecules and its previously unknown association with metabolic pathologies. Based on SRS microscopy, we have assembled high-throughput platforms for both forward and reverse genetic screens, leading to the discovery of new regulatory mechanisms of lipid metabolism.
Ongoing projects in my laboratory include: (1) investigating the systemic role of lipid signaling in the regulation of longevity; (2) studying the mechanistic link governing the signaling crosstalk between bacteria and host mitochondria; (3) characterizing the cellular and molecular mechanism regulating reproductive homeostasis during aging; (4) analyzing lipid dynamics using quantitative SRS label-free imaging.
Research Interests
Papers共 138 篇Author StatisticsCo-AuthorSimilar Experts
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Shihong Max Gao,Yanyan Qi,Qinghao Zhang, Youchen Guan,Yi-Tang Lee,Lang Ding, Lihua Wang,Aaron S Mohammed,Hongjie Li,Yusi Fu,Meng C Wang
Nature agingpp.1-16, (2024)
Frontiers in molecular biosciences (2024): 1423594-1423594
Daniel C. Brock,Meng Wang,Hafiz Muhammad Jafar Hussain, David E. Rauch,Molly Marra,Mark E. Pennesi,Paul Yang,Lesley Everett,Radwan S. Ajlan, Jason Colbert,Fernanda Belga Ottoni Porto,Anna Matynia,
HUMAN MOLECULAR GENETICS (2024)
Luis A. Jasper,Meng C. Wang
Nature Metabolismno. 1 (2024): 6-7
Katharina Papsdorf,Jason W. Miklas, Amir Hosseini,Matias Cabruja,Christopher S. Morrow,Marzia Savini,Yong Yu,Carlos G. Silva-García,Nicole R. Haseley,Luke Meraz Murphy,Pallas Yao, Elisa de Launoit,
Nature Cell Biologyno. 10 (2023): 1547-1547
Yi-Tang Lee,Marzia Savini, Tao Chen,Jin Yang, Qian Zhao,Lang Ding,Shihong Max Gao,Mumine Senturk,Jessica Sowa,Jue D. Wang,Meng C. Wang
biorxiv(2023)
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