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Diabetes (T1D and T2D); stress-sensitive signaling pathways in pancreatic β-cells that provides cell survival; Epigenetic changes in diabetes and fibroproliferative diseases.
• Research into the fundamental mechanisms underlying changes in gene expression resulting from alterations in the DNA methylation/demethylation
• Elucidating mechanisms whereby nutrients/oxidative stress influence diabetes pathology by re-establishing cellular homeostasis and the DNA methylation profile of
selected diabetes-associated gene loci
• Providing evidence for an “Epi-cure” for diabetic patients, based on targeted DNA methylation that would induce cellular reprograming and/or differentiation.
This work includes several state of the art techniques, such as a novel synthetic epigenetic tool (Epi-CRISPRs) based on CRISPR/cas9 technology for a straightforward, one-step transdifferentiation of pancreatic alpha- to insulin producing cell via targeted DNA methylation and suppression of genes essential for maintaining pancreatic cell identity and MeFISH method for in situ fluorescent visualisation of the 5mC (methylation pattern of the certain gene/region).
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Antioxidants (Basel, Switzerland)no. 3 (2023): 754-754
Journal of engineering & processing managementno. 2 (2022)
Journal of Engineering & Processing Managementno. 2 (2022)
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