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Several small GTPases, including RAS proteins, are functionally modified by the posttranslational modification process of prenylation and post-prenylation methylation. The last step of this modification pathway is catalyzed by a unique enzyme termed isoprenylcysteine carboxylmethyltransferase (ICMT). Genetic and pharmacological evidence supports the importance of ICMT modification of its substrates in oncogenesis and tumor progression. Hence, inhibition of ICMT is a potential approach in the development of novel cancer therapeutics. We are working to: (1) delineate the mechanisms through which ICMT substrate(s) contribute to tumorigenesis and tumor progression, and (2) develop novel ICMT inhibitors for preclinical and clinical development.
Several small GTPases, including RAS proteins, are functionally modified by the posttranslational modification process of prenylation and post-prenylation methylation. The last step of this modification pathway is catalyzed by a unique enzyme termed isoprenylcysteine carboxylmethyltransferase (ICMT). Genetic and pharmacological evidence supports the importance of ICMT modification of its substrates in oncogenesis and tumor progression. Hence, inhibition of ICMT is a potential approach in the development of novel cancer therapeutics. We are working to: (1) delineate the mechanisms through which ICMT substrate(s) contribute to tumorigenesis and tumor progression, and (2) develop novel ICMT inhibitors for preclinical and clinical development.
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Lalitha Vaishnavi Subramanyan,Suhail Ahmed Kabeer Rasheed, Lijin Wang,Sujoy Ghosh, Michelle Shi Ning Ong,Manikandan Lakshmanan,Mei Wang,Patrick J Casey
Breast cancer research : BCRno. 1 (2024): 113-113
Nature Reviews Cancerno. 4 (2024): 1-21
Suhail Ahmed Kabeer Rasheed, Lalitha Vaishnavi Subramanyan,Wei Kiang Lim,Udhaya Kumari Udayappan,Mei Wang,Patrick J. Casey
ONCOGENEno. 2 (2022): 147-158
Suhail Ahmed Kabeer Rasheed, Lalitha Vaishnavi Subramanyan,Wei Kiang Lim,Udhaya Kumari Udayappan,Mei Wang,Patrick J Casey
Suhail Ahmed Kabeer Rasheed, Lalitha Vaishnavi Subramanyan,Wei Kiang Lim,Udhaya Kumari Udayappan,Mei Wang,Patrick J. Casey
Oncogeneno. 2 (2021): 147-158
CELLSno. 1 (2020)
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