基本信息
浏览量:2
职业迁徙
个人简介
Dr. Ali is a pulmonary vascular and airway disease biology researcher. Specifically, he is interested in investigating the mechanisms that underpin development of pulmonary arterial hypertension (PAH), hereditary hemorrhagic telangiectasia (HHT) and asthma. His overarching goal is to discover improved therapies for individuals with the devastating form of the lung diseases.
His academic training and research experience across 4 nations and 3 continents have provided him with an excellent background in multiple biological disciplines, including immunology, molecular biology, microbiology, and cell biology. He received a B.Sc in Biotechnology and Genetic Engineering in 2010 from Khulna University, Bangladesh, an M.Sc. in Systems Biotechnology in 2013 from Chung-Ang University, South Korea, and a PhD in Immunology and Microbiology in 2018 from the University of Newcastle, Australia. Work that he carried out during his PhD on iron and lung disease has been published in the prestigious journals, including Eur Respir J, J Pathol, and received significant media attention (picked up by > 10 news outlets so far) and formed the basis for one project grant. In Nov 2018, he joined Spiekerkoetter laboratory at Stanford to identify clinically significant novel bone morphogenic protein receptor 2 (BMPR2) signaling modifier genes that could be targeted with repurposed drugs to increase BMPR2 expression and signaling, one of the key pathways and potential master switch in PAH. In addition, lessons from this related genetic disease (PAH), he started to work on dysfunctional TGF-β/BMPR2 signaling in HHT that causes vascular malformations in different organs, including the lung. He identified a drug, Brivanib that can target two key signaling pathways (BMPR2, and VEGF) and improve pulmonary vascular cell functions.
To date, he has published 38 articles and >30 conference papers in top tier prestigious journals, including Eur Respir J, J Pathol, Am J Respir Crit Care Med, Cardiovascular Res (total citations 940, h index 14, as of June 2023). He has so far received 12 awards and scholarships. He has mentored 5 undergraduate and 1 junior PhD students, demonstrated immunology and microbiology lab courses for 3 years. Currently, he is working as a reviewer for prestigious journals and member of 12 scientific organizations. Also, he has been serving as a member of the Stanford Cardiovascular Institute postdoc early carrier committee since 2020.
Beyond academic professional life, he enjoys traveling, playing and watching cricket, watching movies.
Research interest:
1.Targeting BMPR2 signaling modifiers in PAH with repurposed drugs
2.Role of long non-coding RNAs in BMPR2 signaling in PAH
3.Identifying common and unique downstream genes and signaling pathways of HHT causing gene mutations (ALK1, ENG, SMAD4)
4.Role of ferroptosis in the pathogenesis of asthma
Key expertise:
In vitro and in vivo lung disease modeling (asthma, COPD, lung fibrosis, cystic fibrosis, and pulmonary hypertension), airway/tissue remodeling, airway/lung inflammation, emphysema, lung fibrosis, lung function, Ex vivo precision cut lung slices, FACS, immune cells phenotypic characterization, handling and production of Haemophilus, Pseudomonas, Chlamydia respiratory infection, bacterial recovery from blood, BAL fluid, and lung, primary lung epithelial, fibroblast, and endothelial cell and cardiac fibroblast culture, cell lines culture, cytotoxic assays, cell proliferation, apoptosis, cytokines detection, shRNA/siRNA-based gene silencing techniques, molecular cloning, gene manipulation, viral vectors, virus production, bacterial culture, transformation, protein expression, isolation, and purification, ELISA, western blot, phosphorylations; histochemical, immunohistochemical techniques (light, fluorescence, confocal microscopy), qPCR, RNAscope, bioinformatics tools such as Gene Trail, Go annotations and KEGG pathways, Panther, MGI, DAVID, STRING network analysis
研究兴趣
论文共 57 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
AMERICAN JOURNAL OF PATHOLOGYno. 3 (2024): 335-337
Lan Zhao, Christine M. Cunningham,Adam M. Andruska,Katharina Schimmel,Md Khadem Ali, Dongeon Kim,Shenbiao Gu, Jason L. Chang,Edda Spiekerkoetter,Mark R. Nicolls
Lab Animalno. 2 (2024): 43-55
The American journal of pathologyno. 3 (2024): 335-337
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2023): 114519-114519
Frontiers in cell and developmental biology (2023): 1149499
bioRxiv : the preprint server for biology (2023)
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023): 1267792-1267792
bioRxiv (Cold Spring Harbor Laboratory) (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn