基本信息
views: 766
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My interest in HLA has included non-classical HLA molecules and their relativesm in particular CD1 and recently the HLA-E. In 1988 Veronique Braud in my group showed that HLA-E bound to a conserved nonamer peptide derived from the signal sequence of classical HLA class I molecules and that this was recognised by the NKG2A/C receptors on natural killer cells, regulating their function. In 2016, we joined a collaboration with Louis Picker and colleagues at OHSU, who had shown that T cells stimulated in rhesus macaques by a cytomegalovirus vectored SIV vaccine are HLA-E restricted. These T cells are able to clear acute SIV infection in approximately 50% of animals after virus challenge. This led us (Geraldine Gillespie, Simon Brackenridge, Lucy Walters, Max Quastel) to explore how HLA-E binds a broad range of peptides, some in an atypical fashion, determining their molecular structures. Using in vitro priming techniques, we (Hongbing Yang, Hong Sun) have been able to demonstrate human CD8 T cells specific for HIV, SARS Coronavirus-2 and self antigenic peptides presented by HLA-E. We are currently working on virus specific and tumour specific HLA-E restricted T cells with an interest in developing immuno-therapies that could be applied universally because of the very limited polymorphism of HLA-E.
Research Interests
Papers共 773 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature reviews. Immunologypp.1-17, (2024)
FRONTIERS IN IMMUNOLOGY (2024): 1329032-1329032
Joyce K Hwang,Daniel J Marston,Daniel Wrapp,Dapeng Li,Marina Tuyishime,Simon Brackenridge,Brianna Rhodes,Max Quastel,A Brenda Kapingidza, Jacob Gater, Austin Harner,Yunfei Wang,
bioRxiv : the preprint server for biology (2024)
Barton F. Haynes, Kevin Wiehe, Persephone Borrow, Kevin O. Saunders, Bette Korber, Kshitij Wagh,Andrew J. McMichael, Garnett Kelsoe, Beatrice H. Hahn, Frederick Alt, George M. Shaw
NATURE REVIEWS IMMUNOLOGYno. 4 (2023): 265-265
NATURE COMMUNICATIONSno. 1 (2023)
Nature Communicationsno. 1 (2023)
Zhansong Lin,Arman A. Bashirova,Mathias Viard,Lee Garner,Max Quastel,Maya Beiersdorfer,Wojciech K. Kasprzak, Marjan Akdag,Yuko Yuki, Pedro Ojeda,Sudipto Das,Thorkell Andresson,
Load More
Author Statistics
#Papers: 795
#Citation: 78875
H-Index: 138
G-Index: 264
Sociability: 8
Diversity: 0
Activity: 1
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn