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个人简介
In the McDonald lab, we are taking an integrated systems approach to the study of cancer. This means that we view cancer not as a defect in any particular gene or protein, but as a de-regulated cellular/inter-cellular process. An understanding of such complex processes requires the implementation of experimental approaches that can provide an integrative holistic or 'systems' view of intra-and inter-cellular process. We employ a number high-throughput genomic (e.g., DNA-seq, RNA-seq, microarray) technologies to gather systems data on the status of cancer cells. We strive to integrate into our research program, the exceptional strengths that exist at Georgia Tech in the fields of engineering and the computational sciences.
Our current goals are:
1) development of a generalized cancer diagnostic using mass spectrometric metabolic profiling;
2) development of small non-encoding RNAs as potential therapeutic agents and the use of functionalized nanoparticles (nanohydrogels) for their targeted delivery to cancer cells; and
3) exploring the significance of mRNA splice variants in the onset and progression of cancer.
研究兴趣
论文共 299 篇作者统计合作学者相似作者
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GEN BIOTECHNOLOGYno. 2 (2024): 87-96
Gynecologic Oncology (2024)
Gynecologic oncology (2024): 143-143
GYNECOLOGIC ONCOLOGY (2024): 168-175
Stephen N. Housley,Sebinne Lee,Lilya V. Matyunina, Olivia A. Herrmann,Minati Satpathy, Johana C. Arboleda,John F. McDonald,M.G. Finn
biorxiv(2024)
ZOOSYSTEMATICS AND EVOLUTIONno. 1 (2023): 55-62
PLOS global public healthno. 2 (2023): e0001560
Katherine M Young,Congmin Xu,Kelly Ahkee,Roman Mezencev,Steven P Swingle,Tong Yu, Ava Paikeday, Cathy Kim,John F McDonald,Peng Qiu,Todd Sulchek
iScienceno. 4 (2023): 106393-106393
International journal of molecular sciencesno. 13 (2023): 10823-10823
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