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His research activity is especially focused on mathematical modeling and computer simulation of complex physiological systems. This research activity is presently subdivided into two main fields:
Modeling of cardiovascular regulation – i) He realized several original studies on mechanisms controlling local blood flow to tissues, with special emphasis on the cerebral circulation and intracranial pressure dynamics. These models have been applied for the analysis of patients in neurosurgical Intensive Care Units. A recent version of the model incorporates the complex anastomoses characterizing cerebral venous return to the heart. ii) He developed models of cardio-respiratory regulation in the short time, able to summarize the complex integration among the various mechanisms operating in response to various acute hemodynamic perturbations (haemorrhage, alterations in blood gas content, dynamical exercise). Other models are focused on the integration between cardiovascular dynamics, and solute kinetics during hemodialysis, and are currently used in some advanced Nephrology Units in Italy.
ii) Modeling of neurosensory integration and cognitive processes – i) He realized some mathematical models of the primary visual cortex, and models describing the integration among different sensory modalities (auditory, visual and tactile). The aim is to reach a deeper theoretical understanding of the neural mechanisms involved in multisensory integration, and devise a possible use in the clinical practice, to improve cognitive deficits. In particular, these models can explain some typical illusory phenomena occurring during audio-visual interactions (such as the Ventriloquism and the fission effects), the maturation of multisensory capacities during the first weeks after birth, and the modification in the visuo-tactile peripersonal space induced by a tool use. ii) Other models of neural populations have been used to estimate functional connectivity among different brain regions during simple cognitive or motor tasks, and to formulate hypotheses on the role of oscillations in brain electrical activity. These models allow a quantitative simulation of many different oscillatory phenomena (in the alpha, beta, gamma and delta frequency ranges) in different cortical areas and their reciprocal interactions during sleepiness or wakefulness. Models of oscillating neural populations are also used to analyse the behaviour of place cells in the hippocampus during navigation tasks.
iii) Further model investigates the neural mechanisms involved in semantic memory, i.e., how object semantics can be created starting from a recurring presentation of their elementary features. The model allows the formulation of hypotheses on the organisation of the semantic memory in the brain and on its the relationship with language.
iv) A recent biologically inspired neural network model simulates action choice and reinforcement learning in the basal ganglia. The model can be used to assess bradykinesia in Parkinsonian subjects, as a consequence of dopamine depletion, and to investigate the optimal strategy for levodopa treatment.
His scientific production presently includes about 346 publications (among them, 169 papers on peer reviewed international journals and 25 on international books).
Modeling of cardiovascular regulation – i) He realized several original studies on mechanisms controlling local blood flow to tissues, with special emphasis on the cerebral circulation and intracranial pressure dynamics. These models have been applied for the analysis of patients in neurosurgical Intensive Care Units. A recent version of the model incorporates the complex anastomoses characterizing cerebral venous return to the heart. ii) He developed models of cardio-respiratory regulation in the short time, able to summarize the complex integration among the various mechanisms operating in response to various acute hemodynamic perturbations (haemorrhage, alterations in blood gas content, dynamical exercise). Other models are focused on the integration between cardiovascular dynamics, and solute kinetics during hemodialysis, and are currently used in some advanced Nephrology Units in Italy.
ii) Modeling of neurosensory integration and cognitive processes – i) He realized some mathematical models of the primary visual cortex, and models describing the integration among different sensory modalities (auditory, visual and tactile). The aim is to reach a deeper theoretical understanding of the neural mechanisms involved in multisensory integration, and devise a possible use in the clinical practice, to improve cognitive deficits. In particular, these models can explain some typical illusory phenomena occurring during audio-visual interactions (such as the Ventriloquism and the fission effects), the maturation of multisensory capacities during the first weeks after birth, and the modification in the visuo-tactile peripersonal space induced by a tool use. ii) Other models of neural populations have been used to estimate functional connectivity among different brain regions during simple cognitive or motor tasks, and to formulate hypotheses on the role of oscillations in brain electrical activity. These models allow a quantitative simulation of many different oscillatory phenomena (in the alpha, beta, gamma and delta frequency ranges) in different cortical areas and their reciprocal interactions during sleepiness or wakefulness. Models of oscillating neural populations are also used to analyse the behaviour of place cells in the hippocampus during navigation tasks.
iii) Further model investigates the neural mechanisms involved in semantic memory, i.e., how object semantics can be created starting from a recurring presentation of their elementary features. The model allows the formulation of hypotheses on the organisation of the semantic memory in the brain and on its the relationship with language.
iv) A recent biologically inspired neural network model simulates action choice and reinforcement learning in the basal ganglia. The model can be used to assess bradykinesia in Parkinsonian subjects, as a consequence of dopamine depletion, and to investigate the optimal strategy for levodopa treatment.
His scientific production presently includes about 346 publications (among them, 169 papers on peer reviewed international journals and 25 on international books).
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Journal of neural engineeringno. 3 (2023)
JOURNAL OF INTEGRATIVE NEUROSCIENCEno. 1 (2023): 3-3
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IBRO Neuroscience Reports (2023): S795-S795
Nephrology Dialysis Transplantationno. Supplement_3 (2022): I540-I541
COGNITIVE NEURODYNAMICSno. 2 (2022): 489-521
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