The translational research of our Research Division is fully geared by a systematic translational pipeline of developing therapy strategies for a broad range of genetically stratified neurodegenerative diseases. It proceeds from discovering the genetic basis, via fluid and digital biomarkers to paradigmatic first-in-human therapy approaches in
ataxia and ataxia-overlap diseases, in particular genetic ataxias, complicated hereditary spastic paraplegias (HSP) , neurometabolic diseases, and rare complex movement disorders
Frontotemporal Dementia, Alzheimer’s Disease, and other complex dementias, e.g. early-onset dementias, rare and atypical variants of Alzheimer´s disease, genetic dementias neurometabolic dementias.
motor neuron diseases: Amyotrophic Lateral Sclerosis, in particular genetic types; ALS-FTD spectrum diseases, lysosomal motor neuron diseases.