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The overarching goal of Dr. Kretzler's research is to define chronic kidney disease in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he and his team have developed a translational research pipeline centered on integrated systems biology analysis of renal disease.
Dr. Kretzler has 25 years of experience on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the United States, Europe, China, and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanisms identified have resulted in new disease predictors, new drug development and successful clinical trials of novel therapeutic modalities in chronic kidney disease.
Dr. Kretzler has 25 years of experience on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the United States, Europe, China, and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanisms identified have resulted in new disease predictors, new drug development and successful clinical trials of novel therapeutic modalities in chronic kidney disease.
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论文共 671 篇作者统计合作学者相似作者
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Kidney International Reportsno. 4 (2024): S230
KIDNEY INTERNATIONALno. 2 (2024): 242-244
Cindy I. Varga,Felix Eichinger,Viji Nair,Abhijit S. Naik, Samih H. Nasr S,Agnes B. Fogo, Denis Toskic,Matthias Kretzler, Raymond L. Comenzo R
Kidney International Reports (2024)
Cell Reportsno. 6 (2024)
Pediatric nephrology (Berlin, Germany)pp.1-14, (2024)
Journal of the American Society of Nephrology (2024)
Camille Cohen,Rana Mhaidly, Hugo Croizer,Yann Kieffer,Renaud Leclere, Anne Vincent-Salomon, Catherine Robley, Dany Anglicheau, Marion Rabant,Aurélie Sannier,Marc-Olivier Timsit,Sean Eddy,
Nature Communicationsno. 1 (2024): 1-23
Jonathan P. Troost, Jennifer D’Souza,Miatta Buxton,Abhijit V. Kshirsagar,Lawrence S. Engel, Cassandra R. O’Lenick,William E. Smoyer,Jon Klein,Wenjun Ju,Sean Eddy,Margaret Helmuth,Laura H. Mariani,
Kidney International Reports (2024)
Julio Saez-Rodriguez, Jon Barratt,Haresh Selvaskandan,Raphael Duivenvoorden,Matthias Kretzler,Laura Mariani,Celine Berthier, Anna Witsap,Hannes Olauson,Annika Wernerson,Loreto Gesualdo,Jenny Nyström
Kidney International Reportsno. 4 (2024): S177-S178
Kidney International Reportsno. 4 (2024): S510-S511
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