Matthias Engel - Universitat des Saarlandes

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From Dyrk1A Inhibitors to a Novel Class of Antiviral Agents: Targeting Enterovirus EV-A71 with 2-Aryl-substituted Thiophene Scaffolds

Parthiena M. Keddis, Tuong-Khanh My Tu, Hugo Scherer,Andreas M. Kany,Donia E. Hafez,Sarah S. Darwish,Ashraf H. Abadi,Anna K.H. Hirsch,Matthias Engel,Mostafa M. Hamed, Jim-Tong Horng,Mohammad Abdel-Halim

European Journal of Medicinal Chemistrypp.117348, (2025)

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Discovery of a Novel, Selective CK2 Inhibitor Class with an Unusual Basic Scaffold

Hend Khalifa,Ahmed K. ElHady, Ting Liu,Walid A. M. Elgaher,Odile Filhol-Cochet,Claude Cochet,Ashraf H. Abadi,Mostafa M. Hamed,Mohammad Abdel-Halim,Matthias Engel

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2025)

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Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating Cgmp/pkg Signaling, and Suppressing Β-Catenin-dependent Transcription

Sara Sigler,Mohammad Abdel-Halim,Reem K. Fathalla,Luciana Madeira da Silva,Adam B. Keeton,Yulia Y. Maxuitenko,Kristy Berry,Gang Zhou,Matthias Engel,Ashraf H. Abadi,Gary A. Piazza

Anti-cancer agents in medicinal chemistryno. 1 (2025): 52-62

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Dual Targeting of Inflammation and Β-Cell Dysfunction for Therapy of Diabetes Mellitus

Fayrouz Mustafa,Mohammad Abdel-Halim, Radwa Abdel-Moniem,Shahir Aziz,Sarah S. Darwish, Razan Farrag,Matthias Engel,Salma N. Tammam

Journal of Drug Delivery Science and Technology（2024）

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Discovery of 1,3-Disubstituted Prop-2-en-1-one Derivatives As Inhibitors of Neutrophilic Inflammation Via Modulation of MAPK and Akt Pathways

Mohammad Abdel-Halim,Dalia S. El-Gamil,Mennatallah A. Hammam,Mohamed El-Shazly,Yi-Hsuan Wang, Po-Hsiung Kung,Yu-Cheng Chen,Michal Korinek,Ashraf H. Abadi,Matthias Engel,Tsong-Long Hwang

Journal of Enzyme Inhibition and Medicinal Chemistryno. 1 (2024)

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Development of 5-Hydroxybenzothiophene Derivatives As Multi-Kinase Inhibitors with Potential Anti-Cancer Activity

Yara A. Abd El-Rahman,Po-Jen Chen,Ahmed K. ElHady,Shun-Hua Chen, Hsin-Chieh Lin,Dalia S. El-Gamil,Youssef Aboushady,Ashraf H. Abadi,Matthias Engel,Mohammad Abdel-Halim

FUTURE MEDICINAL CHEMISTRY（2024）

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Originally Designed Dyrk1a Inhibitors as Potent Dyrk1a/Clk1/Clk4/Haspin Multiple Inhibitors: Synthesis and Biological Activities of Sulfur-Containing Tetracycles

Abdelfattah FAOUZI,Alexandre Arnaud,François HALLE, Jean ROUSSEL, Mandy AYMARD, Vincent DENAVIT,Cong Viet DO,Angélique MULARONI,Mohamed SALAH,Ahmed ELHADY, Thanh-Nhat PHAM,Alexandre BANCET, Marc LEBORGNE,Raphaël TERREUX,Roland BARRET,Matthias ENGEL,Thierry LOMBERGET

crossref（2024）

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Development and Evaluation of 2,4-Disubstituted-5-aryl Pyrimidine Derivatives As Antibacterial Agents

Hend Khalifa,Sari Rasheed,Joerg Haupenthal,Jennifer Herrmann,Yasmine M. Mandour,Ashraf H. Abadi,Matthias Engel,Rolf Mueller,Anna K. H. Hirsch,Mohammad Abdel-Halim,Mostafa M. Hamed

Archiv der Pharmazieno. 4 (2024)

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N-Benzylated 5-Hydroxybenzothiophene-2-carboxamides As Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents

Noha Mostafa,Po-Jen Chen,Sarah S. Darwish,Yu-Chieh Su,Ming-Hua Shiao,Gary A. Piazza,Ashraf H. Abadi,Matthias Engel,Mohammad Abdel-Halim

Cancersno. 11 (2024): 2033-2033

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Molecular Insights into the Regulatory Landscape of Protein Kinase C-Related Kinase-2 (PRK2/PKN2) Using Targeted Small Compounds

Lissy Z. F. Gross,Angelika F. Winkel,Facundo Galceran,Joerg O. Schulze,Wolfgang Froehner,Simon Caemmerer,Stefan Zeuzem,Matthias Engel,Alejandro E. Leroux,Ricardo M. Biondi

JOURNAL OF BIOLOGICAL CHEMISTRYno. 8 (2024)

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