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个人简介
The focus of my research has been on the plasticity and maintenance of the Vibrio cholerae genome. Lateral gene transfer has played a major role in the evolution of pathogenic bacteria because most virulence factors are encoded on mobile genetic elements. My work has focused on two virulence-linked mobile elements in Vibrio cholerae, the agent of cholera. My laboratory has defined several of the molecular steps in the life-cycles of two novel mobile genetic elements: 1) CTXƒÖ, an integrating filamentous phage that encodes cholera toxin, the principal virulence factor of Vibrio cholerae, and 2) SXT, a V. cholerae-derived integrating conjugative element (ICE) that encodes multiple antibiotic resistance genes.
研究兴趣
论文共 341 篇作者统计合作学者相似作者
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Victoria Chevée,Karthik Hullahalli,Katherine G Dailey, Leslie Güereca, Chenyu Zhang,Matthew K Waldor,Daniel A Portnoy
Proceedings of the National Academy of Sciences of the United States of Americano. 17 (2024): e2320311121-e2320311121
Lauren M. Landau, Neha Chaudhary, Yun Chen Tien, Magdalena Rogozinska,Shakchhi Joshi,Conghui Yao, Joseph Crowley,Karthik Hullahalli,Ian W. Campbell,Matthew K. Waldor,Marcia Haigis,Jonathan C. Kagan
Molecular Cellno. 13 (2024): 2436-2454.e10
bioRxiv : the preprint server for biology (2024)
David W Basta,Ian W Campbell, Emily J Sullivan, Julia A Hotinger,Karthik Hullahalli,Matthew K Waldor
bioRxiv : the preprint server for biology (2024)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPYno. 1 (2024): e0119323-e0119323
Herbert G. S. Silva,Satoshi Kimura, Pedro L. C. Lima, David S. Pires,Matthew K. Waldor, Julia P. C. da Cunha
biorxiv(2024)
Current Biologyno. 4 (2024): R133-R134
iScienceno. 6 (2024): 110004-323
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作者统计
#Papers: 337
#Citation: 28748
H-Index: 90
G-Index: 163
Sociability: 7
Diversity: 0
Activity: 2
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