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Matthew is a Research Fellow in the Department of Infectious Diseases, at the Peter Doherty Institute, The University of Melbourne and the Walter and Eliza Hall Institute. Dr Dixon’s research investigates the cellular mechanisms underpinning malaria parasite transmission and disease.
Malaria is a significant global health problem, with more than 200 million clinical cases and up to 400,000 deaths annually . The malaria parasite undergoes remarkable shifts in cellular structure, as it progresses from life within the red blood cells of the vertebrate human host to a free living sexual form within the invertebrate insect vector. Transmission of the parasite from human to mosquito requires the formation of a highly-specialised parasite form called a gametocyte. Gametocyte maturation represents a “bottle neck” in the parasite’s development; inhibition of this process would ablate disease transmission. Despite the importance of this stage of the parasite to transmission we understand very little about its unique biology.
Dr Dixon's research uses a combination of research techniques including CRISPR gene editing proteomics, quantitative PCR of ex vivo samples from controlled human malaria infections , molecular and cellular biology techniques and super resolution microscopy to define the molecular players driving gametocyte development and transmission. Understanding the unique biology of these specialised sexual stage gametocytes will help guide much needed new approaches aimed at disease eradication.
Malaria is a significant global health problem, with more than 200 million clinical cases and up to 400,000 deaths annually . The malaria parasite undergoes remarkable shifts in cellular structure, as it progresses from life within the red blood cells of the vertebrate human host to a free living sexual form within the invertebrate insect vector. Transmission of the parasite from human to mosquito requires the formation of a highly-specialised parasite form called a gametocyte. Gametocyte maturation represents a “bottle neck” in the parasite’s development; inhibition of this process would ablate disease transmission. Despite the importance of this stage of the parasite to transmission we understand very little about its unique biology.
Dr Dixon's research uses a combination of research techniques including CRISPR gene editing proteomics, quantitative PCR of ex vivo samples from controlled human malaria infections , molecular and cellular biology techniques and super resolution microscopy to define the molecular players driving gametocyte development and transmission. Understanding the unique biology of these specialised sexual stage gametocytes will help guide much needed new approaches aimed at disease eradication.
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