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个人简介
The Soellner laboratory is devoted to the study of cancer pharmacology. Specifically, we aim to develop novel therapeutics and use these inhibitors to understand oncogenic signaling in breast cancer. My laboratory routinely performs organic synthesis, medicinal chemistry optimization, and biochemical and cellular evaluations (including microscopy and flow cytometry) of potential therapeutics.
My laboratory works on fundamental and applied approaches to: (a) Identify mechanisms that modulate kinase conformation, (b) Explore stabilizing kinase conformations with small molecules, and (c) Utilize these finding to generate selective inhibitors that can stabilize particular protein conformations for improved signaling inhibition. Towards these goals, we have developed a robust ‘selective proteolysis’ methodology that can identify changes in protein kinase conformation. Further, we are developing kinase inhibitors that stabilize various global conformations of these kinases to interrogate how modulating both catalytic and scaffolding functions can be utilized as a novel approach for targeting the kinome.
My laboratory works on fundamental and applied approaches to: (a) Identify mechanisms that modulate kinase conformation, (b) Explore stabilizing kinase conformations with small molecules, and (c) Utilize these finding to generate selective inhibitors that can stabilize particular protein conformations for improved signaling inhibition. Towards these goals, we have developed a robust ‘selective proteolysis’ methodology that can identify changes in protein kinase conformation. Further, we are developing kinase inhibitors that stabilize various global conformations of these kinases to interrogate how modulating both catalytic and scaffolding functions can be utilized as a novel approach for targeting the kinome.
研究兴趣
论文共 76 篇作者统计合作学者相似作者
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Cancer research communicationsno. 6 (2023): 1093-1103
Amanda L Peiffer,Julie M Garlick,Yujin Wu,Jesse W Wotring, Sahil Arora, Alexander S Harmata,Daniel A Bochar,Corey J Stephenson,Matthew B Soellner,Jonathan Z Sexton,Charles L Brooks,Anna K Mapp
ACS medicinal chemistry lettersno. 6 (2023): 860-866
Aki Morikawa, Jinju Li, Peter Ulintz, Xu Cheng, Athena Apfel,Dan Robinson, Alex Hopkins, Chandan Kumar-Sinha,Yi-Mi Wu, Habib Serhan, Kait Verbal,Dafydd Thomas,
crossref(2023)
Wuxiang Mao,Nathalie M Vandecan, Christopher R Bingham, Pui Ki Tsang,Peter Ulintz, Rachel Sexton,Daniel A Bochar,Sofia D Merajver,Matthew B Soellner
ACS chemical biologyno. 1 (2023): 110-116
Protein Scienceno. 4 (2023)
Nathan M. Merrill,Liwei Bao, Xu Cheng,Nathalie Vandecan,Zhaoping Qin,Albert Liu,Athena Apfel,Laura Goo,Lila Tudrick,Armand Bankhead, Phil Palmbos,Samuel Kaffenberger,
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Angewandte Chemie International Editionno. 46 (2022): e202117276-e202117276
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