Research Summary Matthew Redinbo’s laboratory is focused on structure-function-inhibition studies in vitro and in utilizing suequent animal and ex vivo studies, largely toward the gut microbiota. He employs structural and chemical biology methods, along with biochemistry, cell-sed assays and in vivo model systems to understand how the gut microbiota impacts mammalian health. The work starts at the in vitro level, understanding at the mechanistic level how individual gut microbial enzymes process medically-relevant sutrates, including many drugs. Such approaches are also applied to human nuclear receptors, pulmonary defense proteins, and medically-relevant kinases. The lab then develops potent inhibitors to these enzymes, and tests validated compounds in mouse and rat model systems to examine a range of phenotypes as well as gut microbial next-generation sequencing and metabolomics.