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Our lab works on the clinical and molecular aspects of solid tumours of childhood, particularly germ cell tumours (GCTs) – of which testicular cancer is the most common form. Our work has established emphasis on the role of non-coding RNAs such as microRNAs, which are short, non-protein-coding RNAs that regulate gene expression post-transcriptionally and are aberrantly expressed in cancer. We demonstrated for the first time that the miR-371~373 and miR-302/367 clusters are highly over-expressed in all malignant GCTs, regardless of patient age, histological subtype or anatomical site (published in Cancer Research in 2010). This is a specific change, as these microRNAs are not co-ordinately dysregulated in any other malignancy or disease state. We subsequently were the first to demonstrate the potential utility of specific circulating microRNAs for diagnosis, disease-monitoring and detection of relapse in GCTs as well as other childhood tumours.
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论文共 206 篇作者统计合作学者相似作者
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James C Nicholson,Claire Alapetite, Beate Timmerman,Cecile Faure Conter, Stefan Schönberger,Matthew J Murray,Nicolas Gerber,Andreas Peyrl,Martin Zimmermann, Yasmin Lassen-Ramshad,Didier Frappaz,Rolf-Dieter Kortmann,
Neuro-Oncologyno. Supplement_4 (2024): 0-0
EJC Paediatric Oncology (2024): 100146
Love Goyal,Anna France, Simona Gaito,Rovel J Colaco,Shermaine Pan,Daniel Saunders, Nicola Thorp,Matthew J Murray,James C Nicholson, Thankamma V Ajithkumar,Gillian A Whitfield
Neuro-Oncologyno. Supplement_4 (2024): 0-0
Angus Hodder,Sarah M. Leiter, Jonathan Kennedy,Dilys Addy,Munaza Ahmed,Thankamma Ajithkumar,Kieren Allinson,Phil Ancliff,Shivani Bailey, Gemma Barnard,G. A. Amos Burke, Charlotte Burns,
Frontiers in Oncology (2024)
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Societyno. 3 (2024): 260-265
eClinicalMedicinepp.102453, (2024)
crossref(2023)
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#Papers: 198
#Citation: 3540
H-Index: 30
G-Index: 56
Sociability: 7
Diversity: 3
Activity: 65
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