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Our lab works on the clinical and molecular aspects of solid tumours of childhood, particularly germ cell tumours (GCTs) – of which testicular cancer is the most common form. Our work has established emphasis on the role of non-coding RNAs such as microRNAs, which are short, non-protein-coding RNAs that regulate gene expression post-transcriptionally and are aberrantly expressed in cancer. We demonstrated for the first time that the miR-371~373 and miR-302/367 clusters are highly over-expressed in all malignant GCTs, regardless of patient age, histological subtype or anatomical site (published in Cancer Research in 2010). This is a specific change, as these microRNAs are not co-ordinately dysregulated in any other malignancy or disease state. We subsequently were the first to demonstrate the potential utility of specific circulating microRNAs for diagnosis, disease-monitoring and detection of relapse in GCTs as well as other childhood tumours.
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论文共 203 篇作者统计合作学者相似作者
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EJC Paediatric Oncology (2024): 100146
Angus Hodder,Sarah M Leiter, Jonathan Kennedy,Dilys Addy,Munaza Ahmed,Thankamma Ajithkumar,Kieren Allinson,Phil Ancliff,Shivani Bailey, Gemma Barnard,G A Amos Burke, Charlotte Burns,
Frontiers in oncology (2024): 1421418-1421418
eClinicalMedicine (2024): 102453-102453
crossref(2023)
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JOURNAL OF UROLOGY (2023): E456-E456
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Nature Reviews Urologyno. 8 (2023): 459-460
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#Papers: 198
#Citation: 3791
H-Index: 33
G-Index: 58
Sociability: 7
Diversity: 0
Activity: 3
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