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Bio
Our lab works on the clinical and molecular aspects of solid tumours of childhood, particularly germ cell tumours (GCTs) – of which testicular cancer is the most common form. Our work has established emphasis on the role of non-coding RNAs such as microRNAs, which are short, non-protein-coding RNAs that regulate gene expression post-transcriptionally and are aberrantly expressed in cancer. We demonstrated for the first time that the miR-371~373 and miR-302/367 clusters are highly over-expressed in all malignant GCTs, regardless of patient age, histological subtype or anatomical site (published in Cancer Research in 2010). This is a specific change, as these microRNAs are not co-ordinately dysregulated in any other malignancy or disease state. We subsequently were the first to demonstrate the potential utility of specific circulating microRNAs for diagnosis, disease-monitoring and detection of relapse in GCTs as well as other childhood tumours.
Research Interests
Papers共 196 篇Author StatisticsCo-AuthorSimilar Experts
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EJC Paediatric Oncology (2024): 100146
Love Goyal,Anna France, Simona Gaito,Rovel J Colaco,Shermaine Pan,Daniel Saunders, Nicola Thorp,Matthew J Murray,James C Nicholson, Thankamma V Ajithkumar,Gillian A Whitfield
Neuro-Oncologyno. Supplement_4 (2024): 0-0
Angus Hodder,Sarah M. Leiter, Jonathan Kennedy,Dilys Addy,Munaza Ahmed,Thankamma Ajithkumar,Kieren Allinson,Phil Ancliff,Shivani Bailey, Gemma Barnard,G. A. Amos Burke, Charlotte Burns,
eClinicalMedicinepp.102453, (2024)
crossref(2023)
crossref(2023)
JOURNAL OF UROLOGY (2023): E456-E456
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Nature Reviews Urologyno. 8 (2023): 459-460
crossref(2023)
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Author Statistics
#Papers: 197
#Citation: 3540
H-Index: 30
G-Index: 56
Sociability: 7
Diversity: 3
Activity: 64
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