My research aims to improve the credibility of health and medical research. I have led many studies investigating the transparency, reproducibility and risk of bias in systematic reviews and randomized trials of health interventions and have developed methods to address these issues. I co-led the 2020 update of the PRISMA statement for systematic reviews, and was an associate scientific editor for the 2019 edition of the Cochrane Handbook for Systematic Reviews of Interventions. I co-led the development of a new tool for assessing Risk Of Bias due to Missing Evidence in a synthesis (ROB-ME). I have collaborated on many systematic reviews and meta-analyses evaluating the effects of various interventions for a range of health conditions, including manual therapy and exercise for shoulder pain, splinting for carpal tunnel syndrome, drug and non-drug therapies for attention deficit hyperactivity disorder, and testosterone replacement therapy for sexual wellbeing; this applied work often informs my meta-research agenda.

My expertise has been recognized in leadership and editorial appointments at organizations and journals focusing on meta-research, including co-convenor of the Cochrane Bias Methods Group, and member of the editorial board for the Journal of Clinical Epidemiology and PLOS Medicine.