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个人简介
Group leader: Synapse Biology, i3S Porto (2022-Present)
Research: Astrocytes are one of the major cell types in the mammalian central nervous system (CNS). They perform many important functions, including in synapse formation, maintenance and elimination. Furthermore, they are thought to modulate synaptic transmission at mature synapses (through a variety of mechanisms). Finally, astrocytes are also thought to be crucial for blood brain barrier formation and control of vascular blood flow. However, the molecular mechanisms by which these tasks are accomplished remain unclear. Furthermore, it is unclear if individual astrocytes perform all functions or if specialized astrocyte subtypes exist.
The main research goal of my lab is to understand the degree of astrocyte heterogeneity in the adult mammalian brain and how this impacts on CNS function, with a focus on how astrocytes (differentially) modulate synaptic transmission
As all CNS pathologies show astrocyte involvement – a process known as reactive astrogliosis – we are also interested in the role regional heterogeneity plays in diseases related to aberrant synaptic transmission, with a focus on epilepsy.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
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Jérôme Wahis,Cansu Akkaya, Andre M Kirunda,Aline Mak, Karen Zeise,Jens Verhaert,Hayk Gasparyan,Sargis Hovhannisyan,Matthew G Holt
bioRxiv (Cold Spring Harbor Laboratory) (2024)
GLIA (2023): E509-E509
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Neuroscience (2023): 140-141
Neuroscience (2023)
J. L. Machado,J. F. Viana,D. S. Abreu,S. Barsanti,M. Martins,G. P. Tavares, A. M. Veiga,V. A. M. Sardinha,C. Domingos,A. Pauletti,J. Wahis, C. Liu,
GLIAno. 7 (2023): E510-E510
Frontiers in Cell and Developmental Biology (2023): 1193130-1193130
J. Wahis, A. M. Kirunda, A. Mak, K. Zeise, J. Verhaert, H. Gasparyan,S. Hovhannisyan,L. Arckens,M. G. Holt
GLIA (2023): E1024-E1024
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Neuroscience (2022): 40-51
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作者统计
#Papers: 85
#Citation: 6621
H-Index: 33
G-Index: 66
Sociability: 6
Diversity: 3
Activity: 32
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