Our research focuses on bacterial infections in muco-obstructive lung diseases, a collection of genetic and acquired illnesses including cystic fibrosis (CF), non-CF bronchiectasis, primary ciliary dyskinesia (PCD), and chronic obstructive pulmonary disease (COPD). Individuals with muco-obstructive lung diseases experience progressive respiratory function decline due to recurrent and chronic bacterial infections. Pseudomonas aeruginosa (Pa) is an opportunistic bacterial pathogen and the leading cause of recalcitrant chronic infection in individuals with muco-obstructive lung disease. Our lab seeks to cultivate a more thorough understanding of chronic Pa lung infection pathogenesis using state-of-the-art model systems, including in vitro, in vivo, and ex vivo approaches. Current projects focus on host-microbial and polymicrobial interaction in the context of the lung environment, the impact of antibiotic usage on microbial pathogenesis and population dynamics, and changes in host innate immune metabolism and signaling that contribute to disease progression.