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个人简介
My research activity is focussed on the physiological, genetic and developmental mechanisms underlying the generation and regulation of the heartbeat. During my Ph.D. period at the University of Milan, I contributed to the definition of the biophysical mechanism by which intracellular cAMP regulates cardicac hyperpolarization-activated f-(HCN) channels and modulates heart rate. During my postdoctoral period, I studied the functional role of ancillary subunits of cardiovascular Ca2+ channels pore-forming alpha subunits. Between 2001 and 2005, I have been the first scientist to isolate and study pacemaker cells from the sinus node and the conduction system of the mouse heart. These studies opened the way to the use of mouse genetics in the study of the heart pacemaker mechanism, an approach that is now used by many laboratories worldwide. During the last years, my group described the functional role of several ion channel genes in mouse heart automaticity and impulse conduction including L-type Cav1.3, T-type Cav3.1, f-(HCN4) and IKACh-(Girk4). We also co-authored strong manuscripts on cardiac pacemaking with internationally leading scientists. We pursue three objectives: (1) indicate new therapeutic targets for controlling or improving heart rate, (2) unravel the complex system biology underlying heartbeat control and (3) understanding the impact of the heartbeat in development and evolution. We have created cutting-edge genetic and cellular models of cardiac pacemaker activity and employ state of the art technologies and platforms available in our campus, including electrophysiology, cell biology, genomics, Ca2+ imaging and numerical modelling of pacemaker tissue.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
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Manon Marrot, Yasmine Colombani, Joel Cuoq,Pascaline Fontes, Faustine Hugon,Stephanie Barrere-Lemaire,Nadine Mestre-Francés,Matteo Elia Mangoni,Angelo G. Torrente
Archives of Cardiovascular Diseasesno. 6-7 (2024): S173
Roman Tikhomirov,Robert H. Oakley,Cali Anderson, Yirong Xiang,Sami Al-Othman,Matthew Smith,Sana Yaar,Eleonora Torre, Jianying Li, Leslie R. Wilson,David R. Goulding,Ian Donaldson,
Archives of Cardiovascular Diseasesno. 6-7 (2024): S204
International Journal of Molecular Sciencesno. 6 (2024): 3387
Archives of Cardiovascular Diseasesno. 6-7 (2024): S203
Archives of Cardiovascular Diseases Supplementsno. 2 (2023): 226-227
Proceedings of the National Academy of Sciences of the United States of Americano. 28 (2023)
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作者统计
#Papers: 155
#Citation: 6884
H-Index: 40
G-Index: 82
Sociability: 6
Diversity: 3
Activity: 88
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