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Research interests lie principally with how bacteria sense and respond to environmental change (including changes in external antibiotic concentrations), focusing particularly on the structure and function of bacterial signal transduction pathways (mainly two-component signal transduction systems) and regulators of bacterial gene expression. Research includes investigations of intact sensory proteins(including antibiotic-sensing proteins) that are usually located in the bacterial membrane and are responsible for sensing environmental stimuli and stresses, and also their partner cytosolic regulators that effect appropriate adaptive responses (usually by binding to specific promoters and thereby changing gene expression). The principal systems/regulators (and their associated pathways) under investigation are those found in a range of pathogenic bacteria associated with hospital-acquired infections, including enterococci and methicillin-resistant Staphylococcus aureus. The main approaches and tools of the research are biophysical ones, including circular dichroism spectroscopy and hydrodynamic methods (analytical ultracentrifugation), to investigate ligand -protein interactions of the signal transduction proteins involved, including the intact membrane sensor kinases and phosphorylation-based activity assays to screen and identify candidate signalling ligands and inhibitors (=future antibiotics).
Title: Dr Mary Phillips-Jones BSc MRSC FHEA. Born: Newtown, Powys. Education: School: Priory Grammar School for Girls, Shropshire. University: University College of Wales, Aberystwyth. Qualifications: BSc PhD. Employment: SERC Postdoc, Univ Sheffield (1984-5); MAFF Postdoc, Univ Sheffield Hallam (1985-6); Teaching Fellow, Univ Nottingham (1986-89); MRC & SERC Posdoc, Univ Sheffield (1989-95); Royal Society Visiting Fellow (1995); Senior Lecturer, Univ Leeds (1995-2012) & Univ Centr Lancs (2012-18); Hon Assoc Prof, Univ Nottingham (2017-19); Assoc Prof in Polymer & Microbial Biophysics, Univ Nottingham (2019 - present).
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Scientific reportsno. 1 (2021): 13937-13937
Sean Littlewood, Helena Tattersall,Charlotte S Hughes,Rohanah Hussain,Pikyee Ma,Stephen E Harding,Jiro Nakayama,Mary K Phillips-Jones
Scientific reportsno. 1 (2020): 960-960
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