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Mary K. Estes, Ph.D is a professor at Baylor College of Medicine in Houston, Texas. Her courses include microbiology, and virology; she is also the co-director of the Transitional Biology and Molecular Medicine Graduate Program at Baylor College of Medicine.[1] There are two main viruses that her research is based on, rotaviruses and noroviruses.[2] The main goal of her research are to study how the viral proteins interact with the receptors of the intestinal cells; they are also looking into different ways to deliver virus-like particles to prevent these viruses from causing infections.[1] Estes has achieved many awards and recognition in her time as a virologist. She is also a member of multiple foundations and professional societies.
Through her years as a virologist, Estes has studied rotaviruses and noroviruses in depth. Rotavirus is likely to have infected every child in the world before five years of life. Typically it is not a life-threatening infection, but it can be. Although rotaviruses can infect animals, the research Estes performs concerns its effects on children worldwide. In the 2009 article Rotaviruses: from pathogenesis to vaccination Estes explains the life-threatening side effects of rotavirus infection and the vaccinations that are now being used as a preventative measure.[3] Efforts to develop a successful vaccine against the virus started in the 1980s. Two vaccines were eventually developed —RotaTeq and Rotarix; however, there has been some concern about their safety due to an small increased risk of intussusception. [4] Estes is credited with discovering a novel enterotoxin involved in rotavirus pathology, as well as the effect of histoblood group antigens on an individuals susceptibility to norowalk virus infection. Estes’s laboratory continues to research the molecular mechanisms involved in the pathology of gastrointestinal viruses using recombinant virus-like particles to probe their structure and function.[5] She is also, through collaboration, working on vaccine development for the noroviruses that she studies. The norovirus is the most common cause of acute gastroenteritis worldwide. [6] Studies are underway to discover the correct virus like particle, and create a vaccine to prevent the norovirus.
研究兴趣
论文共 610 篇作者统计合作学者相似作者
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Soni Kaundal, Anish Ramakrishnan,B. Vijayalakshmi Ayyar,Sreejesh Shanker,Gundeep Kaur, Sue E Crawford,Jeroen Pollet,Fabio Stossi,Mary K Estes, B.V. Venkataram Prasad
biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
Grace O Adeniyi-Ipadeola, Julia D Hankins,Amal Kambal,Xi-Lei Zeng, Ketki Patil, Victoria Poplaski,Carolyn Bomidi, Hoa Nguyen-Phuc,Sandra L Grimm,Cristian Coarfa, Fabio Stossi,Sue E Crawford,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
bioRxiv : the preprint server for biology (2023)
Victoria Poplaski,Carolyn Bomidi,Amal Kambal, Nguyen-Phuc Hoa,Sara C. Di Rienzi,Heather A. Danhof,Xi -Lei Zeng,Linda A. Feagins,Nan Deng,Eduardo Vilar,Florencia McAllister,Cristian Coarfa,
Emerging infectious diseasesno. 7 (2023): 1349-1356
David Castillo-Azofeifa,Tomas Wald,Efren A. Reyes,Aaron Gallagher, Julia Schanin, Stephanie Vlachos,Nathalie Lamarche-Vane,Carolyn Bomidi,Sarah Blutt,Mary K. Estes,Todd Nystul,Ophir D. Klein
Antimicrobial agents and chemotherapyno. 10 (2023): e0063623-e0063623
Journal of virologyno. 4 (2023)
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