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个人简介
M. Eileen Dolan, PhD, is a Professor of Medicine at the University of Chicago. She is currently Chair of the Committee on Clinical Pharmacology and Pharmacogenomics that includes a board-certified training program for clinical and post-doctoral fellows. Within the University of Chicago Comprehensive Cancer Center, she is Associate Director for Education and co-leader of the Pharmacogenomics and Experimental Therapeutics Program. Dr. Dolan is an internationally recognized leader in developing cell-based methods to discover genetic variants contributing to chemotherapeutic-induced toxicity, evaluating the relevance of these variants in a clinical setting, and elucidating the biochemical and cellular impact of the variants.
Her existing research program is focused on identifying cancer patients at risk for severe dose-limiting toxicities prior to administration of chemotherapy. Her laboratory was the first to demonstrate that chemotherapeutic-induced cytotoxicity is a heritable trait. Her approach integrates multiple large datasets including: genetic variation, gene expression, miRNA, modified cytosine, transcription factor levels and chemotherapeutic induced pharmacologic traits (cytotoxicity, apoptosis). Her laboratory made the seminal observation that pharmacologic SNPs, identified through genome wide association studies, are enriched in expression quantitative trait loci. Her work has had continual support from the NIH (R01, R21) and, most notably, is co-PI of the U01 “Pharmacogenomics of Anticancer Agents Research (PAAR)” Group, which is part of the Pharmacogenomic Research Network (PGRN) through the NIH/NIGMS.
Dr. Dolan has over 200 publications and has presented her work both nationally and internationally. She has received several awards including the Purdue University Distinguished Women Scholars Award; Purdue University School of Pharmacy Distinguished Alumni Award; University of Dayton Distinguished Alumni Award; American Cancer Society Ambassador of Hope; American Cancer Society, IL Presidential Award for Volunteer Contributions to Research. As a volunteer for the American Cancer Society, she has given over 60 talks to raise money for cancer research and was instrumental in initiating the high school program.
Dr. Dolan has a Bachelor of Science degree in Chemistry from University of Dayton and PhD in Medicinal Chemistry from Purdue University. Her post-doctoral training was at Pennsylvania State University School of Medicine in Hershey, PA. She has been a faculty member at the University of Chicago since 1989 and has served in a number of leadership positions. She served for a decade on the Biological Sciences Division Committee of Reappointment of Assistant Professors including serving as chair for 5 years and currently chairs the University Committee on Academic Fraud. She has trained numerous students including high school, undergraduate, graduate, postdoctoral and clinical fellows.
研究兴趣
论文共 113 篇作者统计合作学者相似作者
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JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): 12092-12092
Geneticsno. 1 (2023)
crossref(2023)
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作者统计
#Papers: 113
#Citation: 4847
H-Index: 23
G-Index: 55
Sociability: 7
Diversity: 2
Activity: 18
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