基本信息
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Bio
The current focus of Dr. Goldring’s laboratory is on the mechanisms of gene regulation by which stress- and inflammation-induced signals induce expression of matrix metalloproteinase 13 (MMP-13), the pivotal collagen-degrading proteinase that marks osteoarthritis progression, as well as other catabolic and anabolic responses in cartilage and other joint tissues. Her laboratory has found that there are common mediators of these processes in human OA cartilage that are also involved in mechanotransduction, including the protein kinases, IKKs and MAPKs. These pathways converge on transcriptional regulation of MMP13, IL1B, and other key genes by NF-kB, Elf3, C/EBPb, Runx2, and hypoxia-inducible factor (HIF) 2a.
Research Interests
Papers共 360 篇Author StatisticsCo-AuthorSimilar Experts
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Adrien Y. Antoinette,Sophia N. Ziemian, Allison R. Brown, Erin B. Hudson,Carolyn Chlebek,Timothy M. Wright,Steven R. Goldring,Mary B. Goldring,Miguel Otero,Marjolein C. H. van der Meulen
Molecular Pharmaceuticsno. 4 (2024): 1838-1847
Ningrong Chen, Xin Wei, Gang Zhao, Zhenshan Jia,Xin Fu, Haochen Jiang, Xiaoke Xu,Zhifeng Zhao,Purva Singh,Samantha Lessard, Miguel Otero,Mary B. Goldring,
Nanomedicine (2024): 102735-102735
Science signalingno. 809 (2023)
Olufunmilayo O. Ayobami,Steven R. Goldring,Mary B. Goldring,Timothy M. Wright,Marjolein C.H. van der Meulen
Eleonora Olivotto,Giovanni Trisolino,Elisa Belluzzi,Antonello Lazzaro,Alessandro Strazzari,Assunta Pozzuoli, Augusto Cigolotti, Pietro Ruggieri, Andrea Evangelista,Francesca Ometto, Stefano Stallone, Steven R. Goldring,
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Author Statistics
#Papers: 363
#Citation: 28537
H-Index: 85
G-Index: 165
Sociability: 7
Diversity: 3
Activity: 15
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