基本信息
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Career Trajectory
Bio
I am a post-doc in cancer biology in the lab of Prof. Andrea Alimonti, one of the worldwide experts in senescence and targeted immunotherapies.
I am working on basic and clinical project to identify novel therapeutic strategies targeting tumor-infiltrating MDSCs, an immune suppressive subset associated with PCa progression and treatment resistance.
During my Ph.D. at the Weizmann Institute, I investigated the impact of p53 mutations in pancreatic cancer, studying cell-non-autonomous gain of functions of p53 missense mutations that shape tumor microenvironment. I am the first author of two manuscripts, one already published in PNAS and another currently in preparation.
In Prof. Moshe Oren’s Lab, I developed extensive experience in bioinformatic analysis of big datasets such as TCGA, basic R studio analysis, bulk and single-cell RNA sequencing, and molecular cell biology techniques from qRT-PCR, to Western Blot and immunoprecipitation. I worked comprehensively with different mouse models, especially pancreatic cancer orthotopic xenografts that allowed me to learn how to carry out complex surgeries, collect mouse samples and dissociate tumors. Furthermore, I mastered immunohistochemistry techniques from basic to multiplex stainings of mouse tissues and human tissue microarrays.
As a visiting student in the Cold Spring Harbour Laboratory (in the David Tuveson Laboratory), I tested the efficacy of peptides in restoring the WT conformation of mutant p53 in human and mouse pancreatic cancer organoids.
My goal is to expand my knowledge of immunotherapy and tissue microenvironment perturbation. I aim to acquire new technical and managerial skills to increase the relevance and competitiveness of my profile.
Research Interests
Papers共 7 篇Author StatisticsCo-AuthorSimilar Experts
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Daniela Brina, Adele Ponzoni,Martina Troiani,Bianca Calì,Emiliano Pasquini,Giuseppe Attanasio,Simone Mosole,Michela Mirenda, Mariantonietta D’Ambrosio,Manuel Colucci,Ilaria Guccini,Ajinkya Revandkar,
Research Square (Research Square) (2021)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
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