基本信息
views: 43
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research
Biogenesis of mitochondrially encoded proteins
Mitochondria allow our cells to use oxidative phosphorylation as a highly efficient way to generate ATP. The membrane-bound respiratory chain complexes are composed of proteins from two different genetic origins, namely the nuclear and the mitochondrial DNA. The research of our group is focused on the synthesis and assembly of the mitochondrially encoded proteins. Defects in the expression of mitochondrial genes can cause or influence many human diseases including cancer, aging and mitochondrial disorders. However, surprisingly little is known about the molecular mechanisms underlying the biogenesis of mitochondrially encoded proteins. We employ a large variety of biochemical, cell and molecular biology methods to gain mechanistic insights into this fundamental process.
Biogenesis of mitochondrially encoded proteins
Mitochondria allow our cells to use oxidative phosphorylation as a highly efficient way to generate ATP. The membrane-bound respiratory chain complexes are composed of proteins from two different genetic origins, namely the nuclear and the mitochondrial DNA. The research of our group is focused on the synthesis and assembly of the mitochondrially encoded proteins. Defects in the expression of mitochondrial genes can cause or influence many human diseases including cancer, aging and mitochondrial disorders. However, surprisingly little is known about the molecular mechanisms underlying the biogenesis of mitochondrially encoded proteins. We employ a large variety of biochemical, cell and molecular biology methods to gain mechanistic insights into this fundamental process.
Research Interests
Papers共 111 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Andreas Carlström,Martin Ott
Andreas Carlström,Martin Ott
crossref(2024)
Nature Communicationsno. 1 (2024): 1-20
Rachel Hemingway,Steven W. Baertschi,David Benstead,John M. Campbell, Maggie Coombs,Zongyun Huang, Ryan Khalaf,Martin A. Ott,David J. Ponting,Darren L. Reid,Neil G. Stevenson, Samuel J. Webb,
ORGANIC PROCESS RESEARCH & DEVELOPMENTno. 3 (2024): 674-692
EMBO reports (2023)
Methods in molecular biology (Clifton, N.J.) (2023): 119-132
Andreas Kohler, Andreas Carlström,Hendrik Nolte,Verena Kohler,Sung-Jun Jung,Sagar Sridhara,Takashi Tatsuta,Jens Berndtsson,Thomas Langer,Martin Ott
Molecular cellno. 19 (2023): 3470-3484.e8
Acta physiologica (Oxford, England)no. 3 (2023): e13985-e13985
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn